Francis Crick proposed the central dogma of molecular biology more than a half century ago
focusing on the role of RNA as a messenger which delivers genetic information from DNA to …

Long noncoding RNAs (lncRNAs) have emerged as regulators of diverse biological
processes. Here, we describe the initial functional analysis of a poorly characterized human …

Over the past fifteen years, small regulatory RNAs, such as siRNA and miRNA, have been
extensively investigated and the underlying molecular mechanisms have been well …

MicroRNAs (miRNAs) comprise a class of small, regulatory noncoding RNAs (ncRNAs) with
pivotal roles in posttranscriptional gene regulation. Since their initial discovery in 1993 …

A large fraction of mammalian genome can be transcribed to produce various RNAs, of
which only a small subset can serve as the template for protein translation. The RNAs that …

Earlier this year, the scientific community celebrated the 50th anniversary of the Jacob and
Monod Operon Model. In Molecular Cell, a Voices piece in May and a Meeting Review in …

Over the past few decades, the field of RNA research in molecular and cellular biology has
undergone a dramatic transformation. In particular, the study of non-coding RNAs (ncRNAs) …

MicroRNA (miRNA) is a recently identified small non‐coding RNA species that regulates
target gene expression and thereby play significant roles in various life phenomena and …

It has long been assumed that miRNAs can only target protein-coding mRNAs in the
cytoplasm. Recent studies, however, reveal miRNAs are also transported from the cytoplasm …

Among the large, diverse set of mammalian long noncoding RNAs (lncRNAs), long
noncoding primary microRNAs (lnc-pri-miRNAs) are those that host miRNAs. Whether lnc …