Patients with restless legs syndrome exhibit reduced serum colony-stimulating factor-1, humanin-like 3 and 10 levels
Objective The main pathophysiological mechanisms in restless legs syndrome (RLS) are
known as genetic predisposition, brain iron deficiency, and dopaminergic dysfunction. While …
known as genetic predisposition, brain iron deficiency, and dopaminergic dysfunction. While …
Genetic association study of restless legs syndrome in Chinese population
J Chen, Q Luo, G Li, Y Huang, J Ma - European Neurology, 2019 - karger.com
Backgrounds: Several recent case-control studies have suggested some candidate genes
being responsible for causing the restless legs syndrome (RLS). However, the association …
being responsible for causing the restless legs syndrome (RLS). However, the association …
Restless legs syndrome: from pathophysiology to clinical diagnosis and management
S Guo, J Huang, H Jiang, C Han, J Li, X Xu… - Frontiers in aging …, 2017 - frontiersin.org
Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western
countries, has gained more and more attention in Asian countries. The prevalence of RLS is …
countries, has gained more and more attention in Asian countries. The prevalence of RLS is …
Genome-wide association and whole exome sequencing studies reveal a novel candidate locus for restless legs syndrome
Introduction The restless legs syndrome (RLS) is a common heritable neurologic disorder
which is characterized by an irresistible desire to move and unpleasant sensations in the …
which is characterized by an irresistible desire to move and unpleasant sensations in the …
Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis
Objectives Restless legs syndrome (RLS) can lead to severe clinical consequences, thus
negatively impacts on patients' overall health and quality of life. Nevertheless, the …
negatively impacts on patients' overall health and quality of life. Nevertheless, the …
Pathophysiology of restless legs syndrome
M Miyamoto, T Miyamoto, M Iwanami… - Brain and Nerve …, 2009 - europepmc.org
Restless legs syndrome (RLS) is a sensorimotor disorder that is frequently associated with
periodic leg movements (PLMS). RLS is generally considered to be a central nervous …
periodic leg movements (PLMS). RLS is generally considered to be a central nervous …
SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome
XY Zhu, HM Wang, TT Wu, T Liu, YJ Chen, X Li… - Parkinsonism & Related …, 2020 - Elsevier
Background Brain iron disequilibrium and dopaminergic dysfunction are key
pathophysiological features of Restless Legs Syndrome (RLS). Rep1 polymorphism in the …
pathophysiological features of Restless Legs Syndrome (RLS). Rep1 polymorphism in the …
The severity range of restless legs syndrome (RLS) and augmentation in a prospective patient cohort: association with ferritin levels
B Frauscher, V Gschliesser, E Brandauer… - Sleep medicine, 2009 - Elsevier
OBJECTIVES: The aim of the study was to prospectively examine all patients with a
diagnosis of RLS consulting a sleep disorders clinic and to assess RLS severity and …
diagnosis of RLS consulting a sleep disorders clinic and to assess RLS severity and …
Restless legs syndrome
S Clemens - Neurobiology of Brain Disorders, 2023 - Elsevier
Abstract Restless Legs Syndrome (RLS) is a sensorimotor disorder that severely affects
sleep. It has a high prevalence in the population (between 2% and 10%, depending on …
sleep. It has a high prevalence in the population (between 2% and 10%, depending on …
Circulating levels of cytokines are increased in restless legs syndrome
Background Restless legs syndrome [RLS] is known as a disease of iron and dopaminergic
dysregulation but inflammatory processes might also have a role in the pathogenesis. In this …
dysregulation but inflammatory processes might also have a role in the pathogenesis. In this …