Super enhanced permeability and retention (SUPR) effects in tumors following near infrared photoimmunotherapy

H Kobayashi, PL Choyke - Nanoscale, 2016 - pubs.rsc.org
To date, the delivery of nano-sized therapeutic agents to cancers largely relies on enhanced
permeability and retention (EPR) effects that are caused by the leaky nature of cancer …

Near infrared photoimmunotherapy of cancer; possible clinical applications

H Wakiyama, T Kato, A Furusawa, PL Choyke… - …, 2021 - degruyter.com
Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an
antibody-photo-absorber conjugate (APC) composed of a targeting monoclonal antibody …

Improved micro-distribution of antibody-photon absorber conjugates after initial near infrared photoimmunotherapy (NIR-PIT)

T Nagaya, Y Nakamura, K Sato, T Harada… - Journal of Controlled …, 2016 - Elsevier
Near infrared photoimmunotherapy (NIR-PIT), a targeted cancer therapy which uses an
antibody-photo absorber conjugate (APC) and near infrared light exposure, dramatically …

[HTML][HTML] Near-infrared photoimmunotherapy: a comparison of light dosing schedules

F Ogata, T Nagaya, Y Nakamura, K Sato, S Okuyama… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Near infrared photoimmunotherapy (NIR-PIT) is a newly-developed cancer therapy in which
a monoclonal antibody is conjugated to a near-infrared photoabsorber, IR700 to form an …

Markedly enhanced permeability and retention effects induced by photo-immunotherapy of tumors

K Sano, T Nakajima, PL Choyke, H Kobayashi - ACS nano, 2013 - ACS Publications
A major barrier to cancer treatment is the inability to deliver sufficient concentrations of drug
to the tumor without incurring systemic toxicities. Nanomaterials are appealing because they …

Quickly evolving near‐infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment

H Monaco, S Yokomizo, HS Choi, S Kashiwagi - View, 2022 - Wiley Online Library
Among modalities of cancer immunotherapy, near‐infrared photoimmunotherapy (NIR‐PIT)
has reached significant preclinical and clinical stages and quickly evolved over the last 5 …

Contrast-enhanced ultrasound imaging for monitoring the efficacy of near-infrared photoimmunotherapy

K Matsuoka, M Yamada, N Fukatsu, K Goto… - …, 2023 - thelancet.com
Background Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer therapy
combining NIR-light irradiation with an antibody and IR700DX, a light-sensitive substance …

Near-infrared photoimmunotherapy of cancer

H Kobayashi, PL Choyke - Accounts of chemical research, 2019 - ACS Publications
Conspectus This Account is the first comprehensive review article on the newly developed,
photochemistry-based cancer therapy near-infrared (NIR) photoimmunotherapy (PIT). NIR …

Enhanced permeability and retention effect: A key facilitator for solid tumor targeting by nanoparticles

VR Shinde, N Revi, S Murugappan, SP Singh… - Photodiagnosis and …, 2022 - Elsevier
Exploring the enhanced permeability and retention (EPR) effect through therapeutic
nanoparticles has been a subject of considerable interest in tumor biology. This passive …

Near infrared photoimmunotherapy with combined exposure of external and interstitial light sources

Y Maruoka, T Nagaya, K Sato, F Ogata… - Molecular …, 2018 - ACS Publications
Near infrared photoimmunotherapy (NIR-PIT) is a new target-cell-specific cancer treatment
that induces highly selective necrotic/immunogenic cell death after systemic administration …