Hypoxia, a condition of low oxygen tension in tissues, has emerged as a crucial factor in
tumor pathophysiology. Hypoxic microenvironment gives rise to altered cellular metabolism …

A hypoxic microenvironment plays a critical role in the development and progression of
tumors. The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells …

Hypoxia is an important microenvironmental factor that induces cancer metastasis.
Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …

Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

A hypoxic microenvironment leads to cancer progression and increases the metastatic
potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and …

Metastases formation is a major factor in disease progression and accounts for the majority
of cancer deaths. The molecular mechanisms controlling invasion, dissemination to blood or …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Introduction Hypoxia plays a major role in tumor progression, therapy resistance and for
prognosis of oral squamous cell carcinoma (OSCC). The crucial step as a response to …

Hypoxia promotes tumor progression through multiple mechanisms including modifying
angiogenesis, metabolism switch and invasion. Hypoxia inducible factors (HIFs), particularly …