Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
F Grein, A Müller, KM Scherer, X Liu, KC Ludwig… - Nature …, 2020 - nature.com
The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …
positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug …
Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins
J Pogliano, N Pogliano, JA Silverman - Journal of bacteriology, 2012 - Am Soc Microbiol
Daptomycin is a lipopeptide antibiotic used clinically for the treatment of certain types of
Gram-positive infections, including those caused by methicillin-resistant Staphylococcus …
Gram-positive infections, including those caused by methicillin-resistant Staphylococcus …
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Daptomycin is a highly efficient last-resort antibiotic that targets the bacterial cell membrane.
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
Despite its clinical importance, the exact mechanism by which daptomycin kills bacteria is …
[HTML][HTML] Characterization of daptomycin oligomerization with perylene excimer fluorescence: stoichiometric binding of phosphatidylglycerol triggers oligomer formation
JK Muraih, J Harris, SD Taylor, M Palmer - Biochimica et Biophysica Acta …, 2012 - Elsevier
Daptomycin is a lipopeptide antibiotic that binds to and depolarizes bacterial cell
membranes. Its antibacterial activity requires calcium and correlates with the content of …
membranes. Its antibacterial activity requires calcium and correlates with the content of …
[HTML][HTML] Oligomerization of daptomycin on membranes
JK Muraih, A Pearson, J Silverman, M Palmer - Biochimica et Biophysica …, 2011 - Elsevier
Daptomycin is a lipopeptide antibiotic that kills Gram-positive bacteria by membrane
depolarization. While it has long been assumed that the mode of action of daptomycin …
depolarization. While it has long been assumed that the mode of action of daptomycin …
Interaction of daptomycin with lipid bilayers: a lipid extracting effect
Daptomycin is the first approved member of a new structural class of antibiotics, the cyclic
lipopeptides. The peptide interacts with the lipid matrix of cell membranes, inducing …
lipopeptides. The peptide interacts with the lipid matrix of cell membranes, inducing …
[HTML][HTML] Daptomycin forms cation-and size-selective pores in model membranes
TH Zhang, JK Muraih, B MacCormick… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Daptomycin is a lipopeptide antibiotic that is used clinically to treat severe infections caused
by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to …
by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to …
Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery
L Robbel, MA Marahiel - Journal of Biological Chemistry, 2010 - ASBMB
Daptomycin (Cubicin®) is a branched cyclic lipopeptide antibiotic of nonribosomal origin
and the prototype of the acidic lipopeptide family. It was approved in 2003 for the nontopical …
and the prototype of the acidic lipopeptide family. It was approved in 2003 for the nontopical …
More than a pore: a current perspective on the in vivo mode of action of the lipopeptide antibiotic daptomycin
DA Gray, M Wenzel - Antibiotics, 2020 - mdpi.com
Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the
market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections …
market in 2003. To date, it serves as last resort antibiotic to treat complicated skin infections …
Daptomycin: mechanisms of action and resistance, and biosynthetic engineering
RH Baltz - Current opinion in chemical biology, 2009 - Elsevier
Daptomycin is a lipopeptide antibiotic used clinically to treat infections caused by Gram-
positive bacteria. Laboratory studies have shown that Staphylococcus aureus resistance to …
positive bacteria. Laboratory studies have shown that Staphylococcus aureus resistance to …