Hepatitis B virus small envelope protein promotes hepatocellular carcinoma angiogenesis via endoplasmic reticulum stress signaling to upregulate the expression of …

SX Wu, SS Ye, YX Hong, Y Chen, B Wang… - Journal of …, 2022 - Am Soc Microbiol
Hepatocellular carcinoma (HCC) is a hypervascular tumor, and accumulating evidence has
indicated that stimulation of angiogenesis by hepatitis B virus (HBV) may contribute to HCC …

[HTML][HTML] Small hepatitis B virus surface antigen promotes malignant progression of hepatocellular carcinoma via endoplasmic reticulum stress-induced FGF19/JAK2 …

S Wu, S Ye, X Lin, Y Chen, YI Zhang, Z Jing, W Liu… - Cancer Letters, 2021 - Elsevier
Chronic hepatitis B virus (HBV) infection is one of the major global health problems.
Although the small protein of hepatitis B virus surface antigen (HBsAg), SHBs, is the most …

Association of the hepatitis B virus large surface protein with viral infectivity and endoplasmic reticulum stress-mediated liver carcinogenesis

WL Lin, JH Hung, W Huang - Cells, 2020 - mdpi.com
Hepatitis B is the most prevalent viral hepatitis worldwide, affecting approximately one-third
of the world's population. Among HBV factors, the surface protein is the most sensitive …

Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway

H Liu, J Xu, L Zhou, X Yun, L Chen, S Wang, L Sun… - Cancer research, 2011 - AACR
Of the three envelope glycoproteins encoded by hepatitis B virus (HBV) that are collectively
referred to as HBV surface antigen (HBsAg), the large HBsAg (LHBs) glycoprotein is …

Small hepatitis B virus surface antigen promotes hepatic gluconeogenesis via enhancing glucagon/cAMP/protein kinase A/CREB signaling

Y Chen, B Wang, X Ou, Y Wu, Y He, X Lin… - Journal of …, 2022 - Am Soc Microbiol
Hepatitis B virus (HBV) is a major risk factor for serious liver diseases. The liver plays a
unique role in controlling carbohydrate metabolism to maintain the glucose level within the …

Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

H You, D Yuan, Y Bi, N Zhang, Q Li, T Tu, X Wei… - Cell Communication and …, 2021 - Springer
Abstract Background Hepatitis B virus (HBV) X protein (HBX) has been reported to be
responsible for the epithelial-mesenchymal transition (EMT) in HBV-related hepatocellular …

[PDF][PDF] Enhanced expression of vascular endothelial growth factor‐A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis

JC Yang, CF Teng, HC Wu, HW Tsai, HC Chuang… - …, 2009 - Wiley Online Library
Ground glass hepatocytes (GGH) in chronic hepatitis B virus (HBV) infection harbor HBV pre‐
S deletion mutants in endoplasmic reticulum (ER) and exhibit complex biologic features …

Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing S nail protein

H Liu, L Xu, H He, Y Zhu, J Liu, S Wang… - Cancer …, 2012 - Wiley Online Library
A high incidence of tumor recurrence and metastasis has been reported in hepatocellular
carcinoma (HCC) patients with chronic hepatitis B virus (HBV) infection. Although the …

Hepatitis B virus middle protein enhances IL-6 production via p38 MAPK/NF-κB pathways in an ER stress-dependent manner

YX Li, YL Ren, HJ Fu, L Zou, Y Yang, Z Chen - PloS one, 2016 - journals.plos.org
During hepatitis B virus (HBV) infection, three viral envelope proteins of HBV are
overexpressed in the endoplasmic reticulum (ER). The large S protein (LHBs) and truncated …

The serum hepatitis B virus large surface protein as high-risk recurrence biomarker for Hepatoma after curative surgery

HW Tsai, YP Lee, CJ Yen, KH Cheng… - International journal of …, 2022 - mdpi.com
Chronic hepatitis B (CHB) virus infection is the most important cause of HCC and is also
associated with tumor progression. The development of viral biomarkers for HCC prognosis …