Although the local environment is known to regulate neural stem cell (NSC) maintenance in
the central nervous system, little is known about the molecular identity of the signals …

Abstract Background Neural precursor cells (NPCs) are defined by their ability to proliferate,
self-renew, and retain the potential to differentiate into neurons and glia. Deciphering the …

The neural stem cell niche of the embryonic and adult forebrain is rich in chondroitin sulfate
glycosaminoglycans (CS-GAGs) that represent complex linear carbohydrate structures on …

Chondroitin sulfate proteoglycans (CSPGs) play important roles in the developing and
mature nervous system, where they guide axons, maintain stable connections, restrict …

During early postnatal development of the CNS, neuronal networks are configured through
the formation, elimination, and remodeling of dendritic spines, the sites of most excitatory …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

The orderly development of the nervous system is characterized by phases of cell
proliferation and differentiation, neural migration, axonal outgrowth and synapse formation …

The behavior of cells is generally considered to be regulated by environmental factors, but
the molecules in the milieu of neural stem cells have been little studied. We found by …

Chondroitin sulfate proteoglycan (CSPG) is a candidate regulator of embryonic
neurogenesis. The aim of this study was to specify the functional significance of CSPG in …

Neural stem cells have been documented in both the developing and the mature adult CNSs
of mammals. This cell population holds a considerable promise for therapeutical …