Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

Epithelial cell dysfunction has emerged as a central component of the pathophysiology of
diffuse parenchymal diseases including idiopathic pulmonary fibrosis (IPF). Alveolar type 2 …

Pulmonary fibrosis (PF) is characterized by inflammation and fibrosis of the interstitium and
destruction of alveolar histoarchitecture ultimately leading to a fatal impairment of lung …

Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are
essential for the air–blood barrier function of lungs. AT1 cells have been shown to retain …

Generating mature, differentiated, adult lung cells from pluripotent cells, such as induced
pluripotent stem cells and embryonic stem cells, offers the hope of both generating disease …

Alveolar type II (ATII) cells are a key structure of the distal lung epithelium, where they exert
their innate immune response and serve as progenitors of alveolar type I (ATI) cells …

Dating back nearly 35 years ago to the Witschi hypothesis, epithelial cell dysfunction and
abnormal wound healing have reemerged as central concepts in the pathophysiology of …

Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD)
with unknown etiology in which gradual fibrotic scarring of the lungs leads to usual interstitial …