Multi-drug resistant Acinetobacter baumannii is well-known for its rapid acclimatization in
hospital environments. The ability of the bacterium to endure desiccation and starvation on …

Intercellular signal indole and its derivative hydroxyindoles inhibit Escherichia coli biofilm
and diminish Pseudomonas aeruginosa virulence. However, indole and bacterial indole …

The antimicrobial activity of the marine bisindole alkaloid 2, 2-bis (6-bromo-3-indolyl)
ethylamine (1) and related synthetic analogues (compounds 2–8) against target …

The emergence of antibiotic resistance has necessitated new therapeutic approaches to
combat recalcitrant bacterial infections. Persister cells, often found in biofilms, are …

Antimicrobial susceptibilities of 233 Gram-positive and 180 Gram-negative strains to two
novel bis-indoles were evaluated. Both compounds were potent inhibitors of Gram-positive …

Uropathogenic Escherichia coli (UPEC) is a nosocomial pathogen associated with urinary
tract infections and expresses several virulence factors that cause recurring infections and …

Vibrio parahaemolyticus is a food-borne pathogen recognized as the prominent cause of
seafood-borne gastroenteritis globally, necessitating novel therapeutic strategies. This study …

We previously reported a series of N 2, N 4-disubstituted quinazoline-2, 4-diamines as
dihydrofolate reductase inhibitors with potent in vitro and in vivo antibacterial activity against …

Abstract Enterohemorrhagic Escherichia coli O157: H7 (EHEC) is responsible for outbreaks
of hemorrhagic colitis worldwide, but no effective therapy exists for EHEC infections. EHEC …

The emergence of multi-drug resistant pathogenic bacteria represents a serious and
growing threat to national healthcare systems. Most pressing is an immediate need for the …