Neurodegenerative disorders are characterized by progressive loss of particular populations
of neurons. Apoptosis has been implicated in the pathogenesis of neurodegenerative …

In recent years, the investigation of erroneous regulation of apoptotic mechanisms during
acute and chronic injury of neuronal cells has gained increasing attention. Besides acute …

Apoptosis mediates the precise and programmed natural death of neurons and is a
physiologically important process in neurogenesis during maturation of the central nervous …

Apoptosis is an important process in the development of the nervous system. Typically,∼
50% of the neurons apoptose during neurogenesis before the nervous system matures …

Apoptosis has become a most popular concept of cell death. However, the term is now so
widely used and employed in such general terms in relation to neurological diseases that its …

Neuronal cell death in the central nervous system has always been a challenging process to
decipher. In normal physiological conditions, neuronal cell death is restricted in the adult …

Neurodegenerative diseases that include amyotrophic lateral sclerosis, Huntington's
disease, Alzheimer's disease, Parkinson's disease, stroke, brain trauma and spinal cord …

Introduction 3. The apoptosis death machinery 3.1. Signaling via death receptors and
mitochondria 3.2. Caspases: Apoptosis initiation and execution 3.3. Mediators of cellular …

Objective: Progressive cell loss in specific neuronal populations is the prominent
pathological hallmark of neurodegenerative diseases, but its molecular basis remains …

Progressive cell loss in specific neuronal populations often associated with typical
cytoskeletal protein aggregations is a pathological hallmark of neurodegenerative disorders …