[HTML][HTML] Ibudilast attenuates folic acid–induced acute kidney injury by blocking pyroptosis through TLR4-mediated NF-κB and MAPK signaling pathways

X Li, Y Zou, YY Fu, J Xing, KY Wang, PZ Wan… - Frontiers in …, 2021 - frontiersin.org
Folic acid (FA)-induced renal tubule damage, which is characterized by extensive
inflammation, is a common model of acute kidney injury (AKI). Pyroptosis, a pro …

Nilotinib ameliorates folic acid-induced acute kidney injury through modulation of TWEAK and HSP-70 pathways

MS Zaghloul, RS Abdelrahman - Toxicology, 2019 - Elsevier
Abstract Purpose Acute Kidney Injury (AKI) is a global health concern associated with high
morbidity and mortality. Experimental folic acid-induced AKI is comparable to human AKI …

[HTML][HTML] Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway

Y Pang, PC Zhang, RR Lu, HL Li, J Li, HX Fu… - Frontiers in …, 2020 - frontiersin.org
Acute kidney injury (AKI) is a serious disease characterized by a rapid decline in kidney
function. Oxidative stress is the primary pathogenesis of AKI. Salvianolic acid B (SalB), a …

[HTML][HTML] Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice

Q Ren, F Guo, S Tao, R Huang, L Ma, P Fu - Biomedicine & …, 2020 - Elsevier
Background Sepsis is defined as end-organ dysfunction resulting from the host's
inflammatory response to infection. One of the most common sepsis-injured organs is the …

Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice

L Huang, L Zhu, Z Ou, C Ma, L Kong, Y Huang… - International …, 2021 - Elsevier
Betulinic acid (BA) is a pentacyclic triterpenoid compound with potential antioxidant and anti-
inflammatory effects. In this study, T-2 toxin was injected intraperitoneally in mice to establish …

[HTML][HTML] Modulating Nrf-2/HO-1, apoptosis and oxidative stress signaling pathways by gabapentin ameliorates sepsis-induced acute kidney injury

M Abdelnaser, R Alaaeldin, ME Attya… - … schmiedeberg's Archives of …, 2024 - Springer
Purpose Globally, sepsis, which is a major health issue resulting from severe infection-
induced inflammation, is the fifth biggest cause of death. This research aimed to evaluate, for …

[HTML][HTML] 4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling

L Xu, J Cai, C Li, M Yang, T Duan, Q Zhao, Y Xi… - Molecular …, 2023 - Springer
Background Septic acute kidney injury (S-AKI) is the leading form of acute kidney failure
among hospitalized patients, and the inflammatory response is involved in this process. 4 …

[HTML][HTML] Fangjifuling ameliorates lipopolysaccharide-induced renal injury via inhibition of inflammatory and apoptotic response in mice

Z Su, P Yu, L Sheng, J Ye, Z Qin - Cellular Physiology and Biochemistry, 2018 - karger.com
Background/Aims: Acute kidney injury (AKI) is a frequent and serious complication of sepsis;
however, there is no effective treatment for it. FangJiFuling (FF) decoction is widely used to …

Pathway network of pyroptosis and its potential inhibitors in acute kidney injury

N Li, Y Wang, X Wang, N Sun, YH Gong - Pharmacological research, 2022 - Elsevier
Acute kidney injury (AKI) is a worldwide problem, and there is no effective drug to eliminate
AKI. The death of renal cells is an important pathological basis of intrinsic AKI. At present …

[HTML][HTML] Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis

N Li, T Zhao, Y Cao, H Zhang, L Peng… - Frontiers in …, 2021 - frontiersin.org
We previously reported that Tangshen formula (TSF), a Chinese herbal medicine for diabetic
kidney disease (DKD) therapy, imparts renal protective effects. However, the underlying …