Computationally exploring the mechanism of bacteriophage T7 gp4 helicase translocating along ssDNA
Bacteriophage T7 gp4 helicase has served as a model system for understanding
mechanisms of hexameric replicative helicase translocation. The mechanistic basis of how …
mechanisms of hexameric replicative helicase translocation. The mechanistic basis of how …
Dynamic structural insights into the molecular mechanism of DNA unwinding by the bacteriophage T7 helicase
JB Ma, Z Chen, CH Xu, XY Huang, Q Jia… - Nucleic Acids …, 2020 - academic.oup.com
The hexametric T7 helicase (gp4) adopts a spiral lock-washer form and encircles a coil-like
DNA (tracking) strand with two nucleotides bound to each subunit. However, the chemo …
DNA (tracking) strand with two nucleotides bound to each subunit. However, the chemo …
DNA binding in the central channel of bacteriophage T7 helicase-primase is a multistep process. Nucleotide hydrolysis is not required
Many helicases assemble into ring-shaped hexamers and bind DNA in their central channel.
This raises the question as to how the DNA gets into the central channel to form a …
This raises the question as to how the DNA gets into the central channel to form a …
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism
T Lionnet, MM Spiering, SJ Benkovic… - Proceedings of the …, 2007 - National Acad Sciences
Helicases are enzymes that couple ATP hydrolysis to the unwinding of double-stranded (ds)
nucleic acids. The bacteriophage T4 helicase (gp41) is a hexameric helicase that promotes …
nucleic acids. The bacteriophage T4 helicase (gp41) is a hexameric helicase that promotes …
Mechanochemistry of t7 DNA helicase
The bacteriophage T7 helicase is a ring-shaped hexameric motor protein that unwinds
double-stranded DNA during DNA replication and recombination. To accomplish this it …
double-stranded DNA during DNA replication and recombination. To accomplish this it …
DNA unwinding by ring-shaped T4 helicase gp41 is hindered by tension on the occluded strand
The replicative helicase for bacteriophage T4 is gp41, which is a ring-shaped hexameric
motor protein that achieves unwinding of dsDNA by translocating along one strand of ssDNA …
motor protein that achieves unwinding of dsDNA by translocating along one strand of ssDNA …
[引用][C] DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase
One or two of the six subunits of the T7 Page 1 TG 1996 Nature Publishing Group http://www.nature.com/nsmb
correspondence (I DNA is bound within the central hole to One or two of the six subunits of …
correspondence (I DNA is bound within the central hole to One or two of the six subunits of …
The DNA-unwinding mechanism of the ring helicase of bacteriophage T7
Helicases are motor proteins that use the chemical energy of NTP hydrolysis to drive
mechanical processes such as translocation and nucleic acid strand separation …
mechanical processes such as translocation and nucleic acid strand separation …
Single-molecule fluorescence reveals the unwinding stepping mechanism of replicative helicase
Bacteriophage T7 gp4 serves as a model protein for replicative helicases that couples
deoxythymidine triphosphate (dTTP) hydrolysis to directional movement and DNA strand …
deoxythymidine triphosphate (dTTP) hydrolysis to directional movement and DNA strand …
Structural insights into gp16 ATPase in the bacteriophage ϕ29 DNA packaging motor
Biological motors, ubiquitous in living systems, convert chemical energy into different kinds
of mechanical motions critical to cellular functions. Gene product 16 (gp16) in bacteriophage …
of mechanical motions critical to cellular functions. Gene product 16 (gp16) in bacteriophage …