Hoogsteen (HG) base pairs (bps) provide an alternative pairing geometry to Watson–Crick
(WC) bps and can play unique functional roles in duplex DNA. Here, we use structural …

Hoogsteen (HG) base pairing involves a 180° rotation of the purine base relative to Watson–
Crick (WC) base pairing within DNA duplexes, creating alternative DNA conformations that …

Watson–Crick base pairs (bps) are the fundamental unit of genetic information and the
building blocks of the DNA double helix. However, AT and GC can also form alternative …

In 1957, a unique pattern of hydrogen bonding between N3 and O4 on uracil and N7 and N6
on adenine was proposed to explain how poly (rU) strands can associate with poly (rA)‐poly …

Nucleic acids transiently morph into alternative conformations that can be difficult to
characterize at the atomic level by conventional methods because they exist for too little time …

NMR relaxation dispersion studies indicate that in canonical duplex DNA, Watson–Crick
base pairs (bps) exist in dynamic equilibrium with short-lived low abundance excited state …

Houghton (HG) base pairing plays a central role in the DNA binding of proteins and small
ligands. Probing detailed transition mechanism from Watson–Crick (WC) to HG base pair …

Sequence-directed variations in the canonical DNA double helix structure that retain Watson–
Crick base-pairing have important roles in DNA recognition, topology and nucleosome …

Hoogsteen (HG) base pairing is characterized by a 180° rotation of the purine base with
respect to the Watson-Crick-Franklin (WCF) motif. Recently, it has been found that both …

G· C Hoogsteen base pairs can form transiently in duplex DNA and play important roles in
DNA recognition, replication, and repair. G· C Hoogsteen base pairs are thought to be …