HEMATOPOIESIS IS A complex process in which pluripo-tent stem cells proliferate and
differentiate to generate the full complement of mature blood cells. More than 30 …

Normal steady-state hematopoiesis takes place in the bone marrow microenvironment.
Soluble factors as well as contact interactions between the hematopoietic cells and the …

Abstract Here, Martin Hemler focuses on the emerging field of hematopooetic cell adhesion
to extracellular matrix. Analysis of newly discovered receptor structures involved in cell …

In the adult mammal, haemopoiesis is restricted to the extravascular compartment of the
bone marrow (BM) where primitive haemopoietic stem cells (HSC) and their clonogenic …

Significant progress has been made recently in the understanding of cell adhesion
signaling. Many components of focal adhesion complexes have been identified in fibroblasts …

Hematopoietic progenitor cells are incubated with cytokine combinations for in vitro
expansion of stem cells and to enhance retrovirus-mediated gene transfer. Optimization of …

Associations between hematopoietic cells and their microenvironment are central to the
development and maintenance of a functional hematopoietic system. It is important …

The importance of adhesion receptors in haematopoiesis Stem cells are the basic cellular
units responsible for the development of all tissue and organ systems in the body. It …

Multiple adhesion receptors are involved in the interaction of hematopoietic cells with the
marrow microenvironment. This work characterizes the expression of various adhesive …

Blood cells developing in the bone marrow exhibit adhesive interactions with stromal
reticular cells and specialized macrophages, and with several defined components of the …