Pulmonary fibrosis is a devastating disease characterized by accumulation of activated
fibroblasts and scarring in the lung. While fibroblast activation in physiological wound repair …

Fibrosis in the lung is thought to be driven by epithelial cell dysfunction and aberrant cell-cell
interactions. Unveiling the molecular mechanisms of cellular plasticity and cell-cell …

Selective repression of the antifibrotic gene CXCL10 contributes to tissue remodeling in
idiopathic pulmonary fibrosis (IPF). We have previously reported that histone deacetylation …

Although DNA methylation has been recognised in the pathogenesis of idiopathic
pulmonary fibrosis (IPF), the exact mechanisms are yet to be fully addressed. Herein, we …

Idiopathic pulmonary fibrosis (IPF) is a devastating fibrotic lung disease of unknown etiology
and limited therapeutic options. In this report, we characterize what we believe is a novel …

Background Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear
pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is …

Pulmonary fibrosis (PF) is an intractable disorder with a poor prognosis. Although lung
fibroblasts play a central role in PF, the key regulatory molecules involved in this process …

There is a paucity of information about potential molecular brakes on the activation of
fibroblasts that drive tissue fibrosis. The transcription factor Krüppel-like factor 4 (KLF4) is …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease. We previously
identified fibrogenic mesenchymal progenitor cells (MPCs) in the lungs of patients with IPF …

Targeted repression of a subset of key genes involved in tissue remodeling is a cardinal
feature of idiopathic pulmonary fibrosis (IPF). The mechanism is unclear but is potentially …