Aspergillus fumigatus is an opportunistic pathogen that is responsible for a life-threatening
fungal infection known as invasive aspergillosis. Current therapies for the treatment of this …

Filamentous fungi rely heavily on the secretory pathway, both for the delivery of cell wall
components to the hyphal tip and the production and secretion of extracellular hydrolytic …

One of the most potent opportunistic fungal pathogens of humans is Aspergillus fumigatus,
an environmental mold that causes a life-threatening pneumonia with a high rate of …

Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand
the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for …

The filamentous fungal pathogen Aspergillus fumigatus secretes hydrolytic enzymes to
acquire nutrients from host tissues. The production of these enzymes exerts stress on the …

The gateway to the secretory pathway is the endoplasmic reticulum (ER), an organelle that
is responsible for the accurate folding, post-translational modification and final assembly of …

Aspergillus fumigatus is a human-pathogenic mold that extracts nutrients from the
environment or from host tissues by secreting hydrolytic enzymes. The ability of A. fumigatus …

The ability of Aspergillus fumigatus to establish and maintain an infection requires a
continuous supply of nutrients to fuel energy production and growth. Like other filamentous …

The unfolded protein response (UPR) is a signaling network that maintains homeostasis of
the endoplasmic reticulum (ER). In the human-pathogenic fungus Aspergillus fumigatus, the …

In the external environment, or within a host organism, filamentous fungi experience sudden
changes in nutrient availability, osmolality, pH, temperature and the exposure to toxic …