Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways

SY Lam, Y Liu, KM Ng, CF Lau, EC Liong… - Histochemistry and cell …, 2012 - Springer
Maladaptive changes in the carotid body (CB) induced by chronic intermittent hypoxia (IH)
account for the pathogenesis of cardiovascular morbidity in patients with sleep-disordered …

Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body

SY Lam, GL Tipoe, EC Liong, ML Fung - Histochemistry and cell biology, 2008 - Springer
The structure and function of the carotid body are greatly altered during chronic hypoxia.
Recent studies showed the expression of interleukin (IL)-1 receptor and IL-6 receptor in the …

Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body

X Liu, L He, L Stensaas, B Dinger… - American Journal of …, 2009 - journals.physiology.org
Exposure to chronic hypoxia (CH; 3–28 days at 380 Torr) induces adaptation in mammalian
carotid body such that following CH an acute hypoxic challenge elicits an abnormally large …

Differential expression of pro-inflammatory cytokines, endothelin-1 and nitric oxide synthases in the rat carotid body exposed to intermittent hypoxia

R Del Rio, EA Moya, R Iturriaga - Brain research, 2011 - Elsevier
The enhanced carotid body (CB) chemosensory response to hypoxia induced by chronic
intermittent hypoxia (CIH) has been attributed to oxidative stress, which is expected to …

Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia

R Del Rio, EA Moya, MJ Parga… - European …, 2012 - Eur Respiratory Soc
Chronic intermittent hypoxia (CIH), a main feature of obstructive sleep apnoea (OSA),
increases hypoxic ventilatory responses and elicits hypertension, partially attributed to an …

Upregulation of a local renin–angiotensin system in the rat carotid body during chronic intermittent hypoxia

SY Lam, Y Liu, KM Ng, EC Liong… - Experimental …, 2014 - Wiley Online Library
New Findings• What is the central question of this study? Expression of the renin–
angiotensin system (RAS) may play a pathogenic role in the augmented activity of carotid …

Chronic intermittent hypoxia-induced vascular enlargement and VEGF upregulation in the rat carotid body is not prevented by antioxidant treatment

RD Rio, C Muñoz, P Arias, FA Court… - … of Physiology-Lung …, 2011 - journals.physiology.org
Chronic intermittent hypoxia (CIH), a characteristic of sleep obstructive apnea, enhances
carotid body (CB) chemosensory responses to hypoxia, but its consequences on CB …

Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia

NR Prabhakar, YJ Peng, G Yuan, J Nanduri - Cell and tissue research, 2018 - Springer
Sleep apnea is a prevalent respiratory disease characterized by periodic cessation of
breathing during sleep causing intermittent hypoxia (IH). Sleep apnea patients and rodents …

Carotid body and cardiorespiratory alterations in intermittent hypoxia: the oxidative link

R Del Rio, EA Moya, R Iturriaga - European Respiratory Journal, 2010 - Eur Respiratory Soc
Intermittent hypoxia, a feature of obstructive sleep apnoea, potentiates ventilatory hypoxic
responses, alters heart rate variability and produces hypertension, partially owing to an …

Cellular mechanisms in intermittent hypoxia-induced cardiac damage in vivo

Q Han, SC Yeung, MSM Ip, JCW Mak - Journal of physiology and …, 2014 - Springer
Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH) during sleep, is
increasingly recognized as an independent risk factor of cardiovascular diseases. OSA is …