Gap junctions interconnect vascular cells homocellularly, thereby allowing the spread of
signals along the vessel wall, which serve to coordinate vessel behavior. In addition, gap …

Please cite this paper as: Sandow SL, Senadheera S, Bertrand PP, Murphy TV, Tare M.
Myoendothelial contacts, gap junctions, and microdomains: anatomical links to function …

Previous findings from our laboratory have shown that dilations to endothelium-derived
hyperpolarizing factor (EDHF) in rat middle cerebral artery (MCA) are less in females …

Key points Electrical signalling in blood vessels is important in acute and long‐term flow
regulation. As myoendothelial gap junctions (MEGJs) provide electrical contacts between …

Highlights•MEGJ are differentially regulated dependent on their connexin
composition.•MEGJ are regulated through post-translational modifications of vascular …

Direct intercellular communication via gap junctions is critical in the control and coordination
of vascular function. In the cardiovascular system, gap junctions are made up of one or more …

A role for myoendothelial gap junctions (MEGJs) has been proposed in the action of the
vasodilator endothelium‐derived hyperpolarizing factor (EDHF). EDHF activity varies in …

A vast amount of investigation has centered on how the endothelium and smooth muscle
communicate. From this evidence, myoendothelial junctions have emerged as critical …

It is becoming increasingly evident that electrical signaling via gap junctions plays a central
role in the physiological control of vascular tone via two related mechanisms (1) the …

Modulation of vascular cell calcium is critical for the control of vascular tone, blood flow and
pressure. 2. Specialized microdomain signalling sites associated with calcium modulation …