Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

On glioblastoma and the search for a cure: where do we stand?

J Bianco, C Bastiancich, A Jankovski… - Cellular and Molecular …, 2017 - Springer
Although brain tumours have been documented and recorded since the nineteenth century,
2016 marked 90 years since Percival Bailey and Harvey Cushing coined the term …

Glioblastoma: molecular pathways, stem cells and therapeutic targets

M Jhanwar-Uniyal, M Labagnara, M Friedman… - Cancers, 2015 - mdpi.com
Glioblastoma (GBM), a WHO-defined Grade IV astrocytoma, is the most common and
aggressive CNS malignancy. Despite current treatment modalities, the survival time remains …

[HTML][HTML] Glioblastoma: new therapeutic strategies to address cellular and genomic complexity

X Cai, ME Sughrue - Oncotarget, 2018 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most invasive and devastating primary brain tumor with a median
overall survival rate about 18 months with aggressive multimodality therapy. Its unique …

Cellular and molecular mechanisms of glioblastoma malignancy: Implications in resistance and therapeutic strategies

J Balça-Silva, D Matias, A do Carmo… - Seminars in cancer …, 2019 - Elsevier
Glioblastoma (GB) is the more frequent and malignant brain tumour. In spite of all efforts, the
median overall survival of GB patients remains approximately 15 months under therapy. The …

Glioblastoma treatment: state-of-the-art and future perspectives

A Rodríguez-Camacho, JG Flores-Vázquez… - International journal of …, 2022 - mdpi.com
(1) Background: Glioblastoma is the most frequent and lethal primary tumor of the central
nervous system. Through many years, research has brought various advances in …

Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review

Y Shen, DKH Thng, ALA Wong, TB Toh - Experimental Hematology & …, 2024 - Springer
Glioblastoma (GBM) is a fatal brain tumour that is traditionally diagnosed based on
histological features. Recent molecular profiling studies have reshaped the World Health …

Revolutionizing Glioblastoma Treatment: A Comprehensive Overview of Modern Therapeutic Approaches

K Sadowski, A Jażdżewska, J Kozłowski… - International Journal of …, 2024 - mdpi.com
Simple Summary Glioblastoma is one of the most dangerous tumors of the central nervous
system, and still cannot be fully overcome. We still mainly rely on standard treatments …

Current and future strategies for the treatment of malignant brain tumors

MG Castro, R Cowen, IK Williamson, A David… - Pharmacology & …, 2003 - Elsevier
Glioblastoma (GB) is the most common subtype of primary brain tumor in adults. These
tumors are highly invasive, very aggressive, and often infiltrate critical neurological areas …

Glioma and glioblastoma‑how much do we (not) know?

I Jovčevska, N Kočevar… - … and clinical oncology, 2013 - spandidos-publications.com
Cancer is a heterogeneous disease, which provides a broad field for investigation, while
simultaneously reducing the chances for a universal treatment. Malignant gliomas are the …