Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …

Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and
development, and tumorigenesis, and has received increasing attention in recent years. In …

Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Wnt proteins are a large family of secreted glycoproteins that activate signal transduction
pathways to control a wide variety of cellular processes suchas determination of cell fate …

Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …

Wnt signaling pathway is one of the most important signaling pathways. The complexity of
Wnt signals and their functional role is crucial in development and growth. It is the most …

The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to
humans. Its activity in the adulthood is less general, with exceptions having huge medical …

The biological functions of some orthologs within the human genome and model-animal
genomes are evolutionarily conserved, but those of others are divergent due to protein …