Antibacterial agents target the products of essential genes but rarely achieve complete
target inhibition. Thus, the all-or-none definition of essentiality afforded by traditional genetic …

Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …

Background Mycobacterium tuberculosis senses and responds to the shifting and hostile
landscape of the host. To characterize the underlying intertwined gene regulatory network …

Identifying genomic elements required for viability is central to our understanding of the
basic physiology of bacterial pathogens. Recently, the combination of high-density …

Although tuberculosis remains a substantial global threat, the mechanisms that enable
mycobacterial persistence and replication within the human host are ill defined. This study …

Abstract Background The human pathogen Mycobacterium tuberculosis has the capacity to
escape eradication by professional phagocytes. During infection, M. tuberculosis resists the …

The ability of Mycobacterium tuberculosis to infect, proliferate, and survive during long
periods in the human lungs largely depends on the rigorous control of gene expression …

Tuberculosis (TB) remains a major health problem worldwide. Attempts to control this
disease have proved difficult owing to our poor understanding of the pathobiology of …

Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted
function, undermining fundamental understanding of pathogenicity and drug susceptibility …

Background With the global emergence of multi-drug resistant strains of Mycobacterium
tuberculosis, new strategies to treat tuberculosis are urgently needed such as therapeutics …