Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …

Extensive degeneration of articular cartilage (AC) is a primary event in the pathogenesis of
osteoarthritis (OA) and other types of joint and bone inflammation. OA results in the loss of …

Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

The role of matrix metalloproteinases in disease has been investigated over the last two
decades. A focus on this family of proteases is particularly emphasized in two major …

Objective We have previously reported the up‐regulation of matrix metalloproteinase 10
(MMP‐10) following treatment with the procatabolic stimulus of interleukin‐1 (IL‐1) and …

Proteolysis of structural molecules of the extracellular matrix (ECM) is an irreversible post-
translational modification in all arthropathies. Common joint disorders, including …

Matrix metalloproteinase-13 (MMP13) is a Zn 2+-dependent protease that catalyzes the
cleavage of type II collagen, the main structural protein in articular cartilage. Excess MMP13 …

In joint diseases of both the inflammatory (rheumatoid arthritis, or RA) or the degenerative
variety (osteoarthritis, or OA), matrix metalloproteinases (MMPs) are essential mediators of …

Objective To investigate the role of matrix metalloproteinase 13 (MMP‐13; collagenase 3) in
osteoarthritis (OA). Methods OA was surgically induced in the knees of MMP‐13–knockout …