Accumulating evidence suggests that E3 ubiquitin ligases play important roles in cancer
development. In this article, we provide a comprehensive summary of the roles of the Nedd4 …

The initiation, progression and cure of cancer rely heavily on altered gene expression and
posttranslational functions. Protein ubiquitination is a major mechanism for posttranslational …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3
ubiquitin ligase, which has been reported to participate in multiple cellular procedures by …

The Neuronally expressed developmentally downregulated 4 (NEDD4), functioning largely
as an E3 ubiquitin ligase, has been demonstrated to play a critical role in the development …

The NEDD4 family of E3 ubiquitin ligases includes nine members. Each is a modular
protein, containing an N-terminal C2 domain for cell localization, two-to-four central WW …

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this
review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is …

Background Nedd4 is a ubiquitin‐protein ligase containing a calcium/lipid‐binding domain,
multiple WW domains and a C‐terminal Hect domain, which is required for both the ubiquitin …

Background EGFR-dependent cell migration plays an important role in lung cancer
progression. Our previous study observed that the HECT E3 ubiquitin ligase NEDD4 is …

Objectives Nedd4 (neural precursor cell expressed developmentally down‐regulated
protein 4) is a member of the HECT E3 ubiquitin ligases, and is elevated in prostate, bladder …