Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …

Mitochondrial dysfunctions have been described in Down syndrome (DS) caused by either
partial or full trisomy of chromosome 21 (HSA21). Mitochondria play a crucial role in various …

Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy
compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is …

There is currently no effective pharmacological therapy to improve the cognitive dysfunction
of individuals with Down syndrome (DS). Due to the overexpression of several chromosome …

Functional and structural damages to mitochondria have been critically associated with the
pathogenesis of Down syndrome (DS), a human multifactorial disease caused by trisomy of …

Down syndrome (DS) or trisomy 21 is the genetic disease with highest prevalence
displaying phenotypic features that both include neurologic deficiencies and a number of …

Mitochondrial dysfunction and oxidative stress are common features of Down syndrome
(DS). However, the underlying mechanisms are not known. We investigated the relationship …

Genome‐wide gene deregulation and oxidative stress appear to be critical factors
determining the high variability of phenotypes in Down's syndrome (DS). Even though …

Down syndrome is the most common genomic disorder of intellectual disability and is
caused by trisomy of chromosome 21. Several genes in this chromosome repress …

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …