Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
Lipid nanoparticle (LNP)-formulated messenger RNA (mRNA) vaccineare a promising
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
platform to prevent infectious diseases as demonstrated by the recent success of SARS-CoV …
Future considerations for the mRNA-lipid nanoparticle vaccine platform
BZ Igyártó, S Jacobsen, S Ndeupen - Current opinion in virology, 2021 - Elsevier
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) pioneered by Katalin
Karikó and Drew Weissman at the University of Pennsylvania are a promising new vaccine …
Karikó and Drew Weissman at the University of Pennsylvania are a promising new vaccine …
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells
S Bevers, SAA Kooijmans, E Van de Velde… - Molecular Therapy, 2022 - cell.com
mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …
Innate immune mechanisms of mRNA vaccines
The lipid nanoparticle (LNP)-encapsulated, nucleoside-modified mRNA platform has been
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
used to generate safe and effective vaccines in record time against COVID-19. Here, we …
A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens
G Swaminathan, EA Thoryk, KS Cox, S Meschino… - Vaccine, 2016 - Elsevier
Sub-unit vaccines are primarily designed to include antigens required to elicit protective
immune responses and to be safer than whole-inactivated or live-attenuated vaccines. But …
immune responses and to be safer than whole-inactivated or live-attenuated vaccines. But …
[HTML][HTML] The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory
Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new
platform used by two leading vaccines against COVID-19. Clinical trials and ongoing …
platform used by two leading vaccines against COVID-19. Clinical trials and ongoing …
A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high
transmissibility of the virus and the high rate of morbidity and mortality associated with …
transmissibility of the virus and the high rate of morbidity and mortality associated with …
Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles
U Elia, S Ramishetti, R Rosenfeld, N Dammes… - ACS …, 2021 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the
causal agent of COVID-19 and stands at the center of the current global human pandemic …
causal agent of COVID-19 and stands at the center of the current global human pandemic …
Lipid nanoparticle-based mRNA candidates elicit potent T cell responses
The induction of a potent T cell response is essential for successful tumor immunotherapy
and protection against many infectious diseases. In the past few years, mRNA vaccines …
and protection against many infectious diseases. In the past few years, mRNA vaccines …
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