Schizophrenia is the eighth leading cause of disability worldwide in people aged 15–44
years. Before antidopaminergic antipsychotics were introduced in the 1950s, no effective …

Importance Antipsychotic drugs constitute the mainstay in the treatment of schizophrenia,
and their efficacy is well established in hundreds of randomized clinical trials. However, it is …

Objective: Antipsychotic drug efficacy may have decreased over recent decades. The
authors present a meta-analysis of all placebo-controlled trials in patients with acute …

Increasingly, it is recognized that first-episode schizophrenia represents a critical stage of
illness during which the effectiveness of therapeutic interventions can affect long-term …

Background The question of which antipsychotic drug should be preferred for the treatment
of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide …

Importance In treatment-resistant schizophrenia, clozapine is considered the standard
treatment. However, clozapine use has restrictions owing to its many adverse effects …

Determining the optimal antipsychotic target dose in acute phase treatment is of high clinical
relevance. The effect of antipsychotics on negative symptoms should be taken into account …

Objective: To comprehensively review the 2 recent and large antipsychotic effectiveness
trials for treatment of schizophrenia: the United Kingdom's Cost Utility of the Latest …

Background The first episode of schizophrenia is a pivotal phase of this debilitating illness.
Which drug to use remains controversial without a summary of all direct or indirect …

OBJECTIVE: The authors conducted a review and meta-analysis of studies that compared
the efficacy and tolerability of typical and second-generation antipsychotics for patients with …