Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …

Leptin is a critical mediator of the immune response to changes in overall nutrition. Leptin is
produced by adipocytes in proportion to adipose tissue mass and is therefore increased in …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

White adipose tissue is currently considered to be an active endocrine organ that secretes a
plethora of factors named adipokines, most of them proinflammatory in nature, which …

Leptin, a 16kDa non-glycosylated polypeptide produced primarily by adipocytes and
released into the systemic circulation, exerts a multitude of regulatory functions including …

Adipose tissue is an active endocrine organ that secretes various humoral factors
(adipokines), and its shift to production of proinflammatory cytokines in obesity likely …

The past twenty years of research on leptin has provided crucial information on the link
between metabolic state and immune system function. Adipocytes influence not only the …

Initially described as an antiobesity hormone, leptin has subsequently been shown also to
influence hematopoiesis, thermogenesis, reproduction, angiogenesis, and immune …

The past few years of research on leptin have provided important information on the link
between metabolism and immune homeostasis. Adipocytes influence not only the endocrine …

After its discovery as a key controller of metabolic function, leptin has been later extensively
implicated in additional functions including important modulatory activities on the innate and …