The hormone renin plays a crucial role in the regulation of blood pressure and fluid-
electrolyte homeostasis. Normally, renin is synthesized by juxtaglomerular (JG) cells, a …

An accumulating body of evidence suggests that renin-expressing cells have developed
throughout evolution as a mechanism to preserve blood pressure and fluid volume …

Hypotension and changes in fluid–electrolyte balance pose immediate threats to survival.
Juxtaglomerular cells respond to such threats by increasing the synthesis and secretion of …

Renin cells emerged in nature> 400 million years ago in bony fish such as zebra fish.
Throughout evolution, the cells retained and possibly perfected essential functions for the …

Renin-synthesizing cells are crucial in the regulation of blood pressure and fluid-electrolyte
homeostasis. Adult mammals subjected to manipulations that threaten homeostasis …

The juxtaglomerular renin-producing cells (RPC) of the kidney are referred to as the major
source of circulating renin. Renin is the limiting factor in renin-angiotensin system (RAS) …

Renin-expressing cells modulate BP, fluid-electrolyte homeostasis, and kidney
development, but remarkably little is known regarding the genetic regulatory network that …

Renin-expressing cells are peculiar in that they act as differentiated cells, producing the
hormone renin, while they also seem to act as progenitors for other renal cell types. As such …

Renin cells are essential for survival perfected throughout evolution to ensure normal
development and defend the organism against a variety of homeostatic threats. During …

Aim Renin cells are essential for regulation of blood pressure and fluid‐electrolyte
homeostasis. During homeostatic threat, the number of renin cells in the kidney increases, a …