Humans have 396 unique, intact olfactory receptors (ORs), G-protein coupled receptors
(GPCRs) containing receptor-specific binding sites; other mammals have more. Activation of …

The vertebrate olfactory system recognizes and discriminates between thousands of
structurally diverse odorants. Detection of odorants in mammals is mediated by olfactory …

The discovery of the odorant receptor (OR) family by Buck and Axel in 1991 provided a
quantum jump in our understanding of olfactory function. However, the study of the …

The olfactory receptor (OR) superfamily provides a basis for the remarkable ability to
recognize and discriminate a large number of odorants. In mice, the superfamily includes∼ …

Highlights•Mammalian ORs undergo rapid evolution at the primary sequence and functional
levels.•Functional differences are more frequently observed among OR paralogs than …

The human nose detects volatile chemical stimuli by at least three different receptor families:
odorant receptors, trace amine‐associated receptors, and vomeronasal type‐1 receptors. As …

Olfactory receptors (ORs) form a large family of G protein-coupled receptor proteins
(GPCRs) responsible for sensing the ambient chemical environment. The molecular …

Sensing the chemical environment is critical for all organisms. Diverse animals from insects
to mammals utilize highly organized olfactory system to detect, encode, and process …

Mammals detect and discriminate numerous odors via a large family of G protein-coupled
odorant receptors (ORs). However, little is known about the molecular and structural basis …

The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily
represents the largest class of membrane protein in the human genome. More than a half of …