Abstract Purpose of Review In patients with prediabetes or type 2 diabetes, the use of
thiazides as antihypertensive agents has been challenged because associated metabolic …

Reduction in the dose of diuretics to treat essential hypertension occurred with the
recognition that higher doses of thiazides cause hypokalemia, glucose intolerance, and …

Although advocated as ''Step 1''in the early Joint National Committee on Prevention,
Detection, Evaluation, and Treatment of High Blood Pressure (JNC) reports, thiazide …

Thiazide diuretics were the first tolerated efficient antihypertensive drugs that significantly
reduced cardiovascular morbidity and mortality in placebo-controlled clinical studies …

Analysis of the available evidence indicates that diuretics do not increase coronary heart
disease morbidity and mortality. The multiclinic trials supporting the cardiotoxicity hypothesis …

Objectives Thiazide diuretics are one of the first choice antihypertensives but not optimally
utilised because of concerns regarding their adverse effects on glucose metabolism. The …

The term thiazide is universally understood to refer to diuretics that exert their principal
action in the distal tubule. The thiazide class is heterogenous and can be further subdivided …

National guidelines and a recent clinical trial have supported the use of thiazide diuretics as
the preferred initial pharmacological treatment for hypertension. However, evidence from …

Background The use of thiazide diuretics has decreased over the past 30 years despite data
from many well-controlled clinical trials demonstrating that the use of these agents as …

This review focuses on thiazides, the diuretics most often indicated for long-term therapy for
hypertension. Thiazide diuretics reduce blood pressure when administered as monotherapy; …