Most animal cells contain a centrosome, which comprises a pair of centrioles surrounded by
an ordered pericentriolar matrix (PCM). Although the role of this organelle in organizing the …

The centrosome, an organelle comprising centrioles and associated pericentriolar material,
is the major microtubule organizing center in animal cells. For the cell to form a bipolar …

Glutamylation is the major posttranslational modification of neuronal and axonemal tubulin
and is restricted predominantly to centrioles in nonneuronal cells (Bobinnec, Y., M. Moudjou …

In animals, somatic cells are usually diploid and are unstable when haploid for unknown
reasons. In this study, by comparing isogenic human cell lines with different ploidies, we …

Centrioles are self-reproducing organelles that form the core structure of centrosomes or
microtubule-organizing centers (MTOCs). However, whether duplication and MTOC …

The role of centrosomes and centrioles during mitotic spindle assembly in vertebrates
remains controversial. In cell-free extracts and experimentally derived acentrosomal cells …

Centrosomes, the predominant sites of microtubule nucleation and anchorage, coordinate
spindle assembly and cell division in animal cells. At the onset of mitosis, centrioles …

A well-established function of centrosomes is their role in accomplishing a successful
mitosis that gives rise to a pair of identical daughter cells. We recently showed that DNA …

ABSTRACT A centrosome consists of a pair of centrioles and pericentriolar material (PCM).
We manipulated expression of PCNT, a key PCM protein, and investigated roles of PCM in …

The maintenance of genome stability is critical for proper cell function, and loss of this
stability contributes to many human diseases and developmental disorders. Therefore, cells …