Silicosis is one of the most prevalent chronic occupational pulmonary diseases worldwide.
The present study aimed to investigate the effects of methyl palmitate on silica-induced lung …

Nicorandil, an antianginal and potassium channel opener agent, has different useful impacts
on cardiovascular and respiratory systems. Its effect against silicosis has not been discussed …

Silicosis is characterized by pulmonary interstitial fibrosis that arises as a result of chronic
exposure to silica. The few available treatments only delay its progression. As α-lipoic acid …

Silicosis is an occupational lung disease caused by inhaling silica dust. The disease is
characterized by early lung inflammation and late irreversible pulmonary fibrosis. Here we …

There is a large body of evidence that nitric oxide (NO) formation is implicated in mediating
silica-induced pulmonary fibrosis. As a reactive free radical, NO may not only contribute to …

Silicosis is a crippling respiratory disorder characterized by massive lung inflammation and
fibrosis. The current study provides evidence on the protective potential of tadalafil; a …

Objective To study the potential of high-dose N-acetylcysteine (NAC) to attenuate silica-
induced pulmonary fibrosis in the rat. Methods Rats exposed to intratracheal instillation of …

Pulmonary fibrosis (PF) is a lethal end stage of interstitial lung disease with increasing
prevalence. The disease burden of PF has seen a sharp surge in the past two decades …

Inhalation of silica particles causes inflammatory changes leading to fibrotizing silicosis.
Considering a lack of effective therapy, and a growing information on the wide actions of …

Due to the production of reactive oxygen species (ROS), oxidative stress has been
implicated in the pathogenesis of silica-induced lung fibrosis. So it is hypothesized that …