Background Typhoid fever is a substantial public health problem in Africa, yet there are few
clinical trials of typhoid conjugate vaccine (TCV). We assessed immunogenicity and safety of …

Background Typhoid fever is an acute infection characterized by prolonged fever following
the ingestion and subsequent invasion of Salmonella enterica serovar Typhi (S. Typhi), a …

Background Typhoid fever is a major public health problem in low-resource settings.
Vaccination can help curb the disease and might reduce transmission. We have previously …

Background Typhoid fever caused by multidrug-resistant H58 Salmonella Typhi is an
increasing public health threat in sub-Saharan Africa. Methods We conducted a phase 3 …

Background Randomised controlled trials of typhoid conjugate vaccines among children in
Africa and Asia have shown high short-term efficacy. Data on the durability of protection …

The disease burden of typhoid fever remains high in endemic areas in Asia and Africa,
especially in children. Recent clinical trials conducted by the Typhoid Vaccine Acceleration …

Abstract Background Salmonella Typhi is a major cause of fever in children in low-and
middle-income countries. A typhoid conjugate vaccine (TCV) that was recently prequalified …

Abstract Objectives In 2017, the World Health Organisation (WHO) pre-qualified a single-
dose typhoid conjugate vaccine (TCV) and identified TCV co-administration studies as a …

Background Zimbabwe suffers from regular outbreaks of typhoid fever (TF), worse since
2017. Most cases were in Harare and a vaccination campaign with Typhoid Conjugate …

Background Typhoid vaccination is a public health priority in developing countries where
young children are greatly affected by typhoid fever. Because present vaccines are not …