Background NSCLC (non-small cell lung cancer) has become the malignancy with the
highest incidence and mortality rate worldwide. Fructose-6-phosphate 2-kinase/fructose-2, 6 …

Abstract Background Phosphofructokinase P (PFKP) is a key rate-limiting enzyme in
glycolysis, playing a crucial role in various pathophysiological processes. However, its …

Colon adenocarcinoma (COAD) is a common malignant tumor, and the role of the protein
PFKFB4 in glycolysis and pentose phosphate pathways is crucial. Researchers investigated …

Abstract Fructose-6-phosphate 2-kinase/fructose-2, 6-bisphosphatase 4 (PFKFB4) is a
crucial enzyme in the glycolysis pathway, possessing both kinase and phosphatase …

Background Cancer cells promote glycolysis, which supports rapid cell growth and
proliferation. Phosphofructokinase-fructose bisphosphatases (PFKFBs), a family of …

Resistance to immunotherapy poses a significant challenge in the treatment of colorectal
cancer (CRC), and the underlying mechanisms are not fully understood. Recent studies …

Background There is growing evidence showing that 6-phosphofructo-2-kinase (PFKFB3)
plays crucial roles in different types of human cancers, including LUAD; however, the …

Abstract Phosphofructokinase-2/fructose-2, 6-bisphosphatase 3 (PFKFB3) catalyzes the
synthesis of F2, 6BP, which is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1) …

Abstract The 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 (PFK-2/FBPase-2,
PFKFB3) is a glycolysis regulatory enzyme and plays a key role in oncogenesis of several …

Gastric cancer (GC) is one of the most common types of cancer worldwide. Previous studies
have reported that phosphofructo‑2‑kinase/fructose‑2, 6‑biphosphatase 4 (PFKFB4) …