Biomaterial‐Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury
TK McGuire, M Stasiewicz, I Woods… - Advanced …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a devastating traumatic injury often causing permanent loss of
function. The challenge of treating SCI stems from the development of a complex …
function. The challenge of treating SCI stems from the development of a complex …
Non-viral gene therapy for spinal cord regeneration
Spinal cord injury (SCI) normally results in life-long disabilities and a broad range of
secondary complications. Advances in therapeutic delivery during the past few decades …
secondary complications. Advances in therapeutic delivery during the past few decades …
Viral-mediated gene therapy for spinal cord injury (SCI) from a translational neuroanatomical perspective
AP Tosolini, R Morris - Neural Regeneration Research, 2016 - journals.lww.com
Repairing spinal cord injury (SCI) is one of the most challenging endeavours currently faced
by neuroscientists. One promising therapeutic avenue to reverse this once considered …
by neuroscientists. One promising therapeutic avenue to reverse this once considered …
Recent advances in nanotherapeutic strategies for spinal cord injury repair
YH Song, NK Agrawal, JM Griffin, CE Schmidt - Advanced drug delivery …, 2019 - Elsevier
Spinal cord injury (SCI) is a devastating and complicated condition with no cure available.
The initial mechanical trauma is followed by a secondary injury characterized by …
The initial mechanical trauma is followed by a secondary injury characterized by …
Gene delivery strategies to promote spinal cord repair: Supplementary issue: Stem cell biology
CM Walthers, SK Seidlits - Biomarker insights, 2015 - journals.sagepub.com
Gene therapies hold great promise for the treatment of many neurodegenerative disorders
and traumatic injuries in the central nervous system. However, development of effective …
and traumatic injuries in the central nervous system. However, development of effective …
Biomaterial-targeted precision nanoparticle delivery to the injured spinal cord
AJ Ciciriello, B Surnar, GD Medy, X Su, S Dhar… - Acta biomaterialia, 2022 - Elsevier
Drug delivery requires precision in timing, location, and dosage to achieve therapeutic
benefits. Challenges in addressing all three of these critical criteria result in poor temporal …
benefits. Challenges in addressing all three of these critical criteria result in poor temporal …
Gene therapy approaches for neuroprotection and axonal regeneration after spinal cord and spinal root injury
X Bo, D Wu, J Yeh, Y Zhang - Current gene therapy, 2011 - ingentaconnect.com
Recent understanding in pathophysiological mechanisms of spinal cord and spinal root
injuries has facilitated the development of new strategies to promote neural repair. Gene …
injuries has facilitated the development of new strategies to promote neural repair. Gene …
Current options for cell therapy in spinal cord injury
Spinal cord injury (SCI) is a complex pathology that evolves after primary acute mechanical
injury, causing further damage to the spinal cord tissue that exacerbates clinical outcomes …
injury, causing further damage to the spinal cord tissue that exacerbates clinical outcomes …
Nanovector‐mediated drug delivery for spinal cord injury treatment
Spinal cord injury (SCI) is the result of a traumatic primary event followed by a so‐called
secondary injury, which is characterized by a large spectrum of biochemical cellular …
secondary injury, which is characterized by a large spectrum of biochemical cellular …
Lentiviral vectors delivered with biomaterials as therapeutics for spinal cord injury
C Shortiss, L Howard, SS McMahon - Cells, 2021 - mdpi.com
Spinal cord injury (SCI) is a devastating trauma that can cause permanent disability, life-long
chronic issues for sufferers and is a big socioeconomic burden. Regenerative medicine aims …
chronic issues for sufferers and is a big socioeconomic burden. Regenerative medicine aims …
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