Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

The brain has the highest mitochondrial energy demand of any organ. Therefore, subtle
changes in mitochondrial energy production will preferentially affect the brain. Considerable …

Neurodegenerative disorders have been considered as a growing health concern for
decades. Increasing risk of neurodegenerative disorders creates a socioeconomic burden to …

While accounting for only 2% of the body's weight, the brain utilizes up to 20% of the body's
total energy. Not surprisingly, metabolic dysfunction and energy supply-and-demand …

Mitochondria are the powerhouse that generate over 90% of the ATP produced in cells. In
addition to its role in energy production, the mitochondrion also plays a major role in …

Mitochondrial respiratory chain disorders are a group of genetically and clinically
heterogeneous disorders caused by the biochemical complexity of mitochondrial respiration …

Mitochondrial deficiencies with unknown causes have been observed in schizophrenia (SZ)
and bipolar disorder (BD) in imaging and postmortem studies. Polymorphisms and somatic …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Mitochondria are intracellular organelles crucial in the production of cellular energy.
Mitochondrial diseases may result from malfunctions in this biochemical cascade. Several …

Mitochondria not only supply the energy for cell function, but also take part in cell signaling.
This review describes the dysfunctions of mitochondria in aging and neurodegenerative …