Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in the
heart. Plasticity and activation are hallmarks of rcMACs in response to changes in the …

Cardiac macrophages represent a heterogeneous cell population with distinct origins,
dynamics, and functions. Recent studies have revealed that CC Chemokine Receptor 2 …

Cardiovascular disease, including myocardial infarction (MI), is the leading cause of death in
the western world. Following MI, a large number of cardiomyocytes are lost and …

Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …

Macrophages represent the most heterogeneous and abundant immune cell populations in
the heart and are central in driving inflammation and reparative responses after cardiac …

Resident cardiac macrophages (rcMacs) are integral components of the myocardium where
they have key roles for tissue homeostasis and in response to inflammation, tissue injury …

Many facets of tissue engineered models aim at understanding cellular mechanisms to
recapitulate in vivo behavior, to study and mimic diseases for drug interventions, and to …

Rationale: The initial hypertrophy response to cardiac pressure overload is considered
compensatory, but with sustained stress, it eventually leads to heart failure. Recently, a role …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Macrophages are found in the heart as part of the inflammatory response. To determine
whether macrophages could contribute to myocardial dysfunction, rat ventricular myocytes …