Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …

Reduced oocyte and embryo quality are recognised as major factors in the problem of
disappointing fertility in high producing dairy cows. This review aims to shed more light on …

Oocyte maturation is a complex and dynamic process regulated by the coordination of
ovarian cells and numerous extraovarian signals. From mammal studies, it is learnt that lipid …

Although obesity negatively influences the metabolic homeostasis of cells within a broad
range of tissues, its impact on oocyte metabolism is not fully understood. Prior evidence …

BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

The periconceptional period, embracing the terminal stages of oocyte growth and post-
fertilisation development up to implantation, is sensitive to parental nutrition. Deficiencies or …

Classic polycystic ovary syndrome (PCOS) is a high-risk phenotype accompanied by
increased risks of reproductive and metabolic abnormalities; however, the local metabolism …

Dynamic metabolism is exhibited by early mammalian embryos to support changing cell
fates during development. It is widely acknowledged that metabolic pathways not only satisfy …

Background Follicular fluid is an important external environment for the growth and
development of oocytes. A thorough identification of specific components in follicular fluid …

Well-balanced and timed metabolism is essential for making a high-quality egg. However,
the metabolic framework that supports oocyte development remains poorly understood …