A review on recent advances in nitrogen-containing molecules and their biological applications

N Kerru, L Gummidi, S Maddila, KK Gangu… - Molecules, 2020 - mdpi.com
The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable
source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by …

Prescribed drugs containing nitrogen heterocycles: an overview

MM Heravi, V Zadsirjan - RSC advances, 2020 - pubs.rsc.org
Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in
a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all …

Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among US FDA approved pharmaceuticals: miniperspective

E Vitaku, DT Smith, JT Njardarson - Journal of medicinal chemistry, 2014 - ACS Publications
Nitrogen heterocycles are among the most significant structural components of
pharmaceuticals. Analysis of our database of US FDA approved drugs reveals that 59% of …

Anti-cancer nitrogen-containing heterocyclic compounds

Z Hosseinzadeh, A Ramazani… - Current Organic …, 2018 - ingentaconnect.com
Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes
and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the …

Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery

S Kumari, K Maddeboina, RD Bachu, SHS Boddu… - Drug Discovery …, 2022 - Elsevier
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds

O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …

Synthetic and biosynthetic routes to nitrogen–nitrogen bonds

HY He, H Niikura, YL Du, KS Ryan - Chemical Society Reviews, 2022 - pubs.rsc.org
The nitrogen–nitrogen bond is a core feature of diverse functional groups like hydrazines,
nitrosamines, diazos, and pyrazoles. Such functional groups are found in> 300 known …

[HTML][HTML] A review: Medicinally important nitrogen sulphur containing heterocycles

PK Sharma, A Amin, M Kumar - The Open Medicinal Chemistry …, 2020 - benthamopen.com
Nitrogen sulphur containing heterocycles have specific properties due to which they can be
used as a potential material in a different type of industries such as medicinal …

Nitrogen-containing heterocycles as anticancer agents: An overview

DK Lang, R Kaur, R Arora, B Saini… - Anti-Cancer Agents in …, 2020 - ingentaconnect.com
Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …