Increasing age has a major detrimental impact on female fertility, which, with an ageing
population, has major sociological implications. This impact is primarily mediated through …

The purpose of this study is to develop a deep radiomic signature based on an artificial
intelligence (AI) model. This radiomic signature identifies oocyte morphological changes …

Background The average age of childbearing has increased over the years contributing to
infertility, miscarriages, and chromosomal abnormalities largely invoked by an age-related …

Advanced maternal age is highly associated with a decline in oocyte quality, but effective
approaches to improve it have still not been fully determined. Here, we report that in vivo …

In mammalian females, quiescent primordial follicles serve as the ovarian reserve and
sustain normal ovarian function and egg production via folliculogenesis. The loss of …

Postovulatory aging would occur to impair the oocyte quality in a timedependent manner if
ovulated oocytes are not fertilized within the optimal timing in the oviduct or in the dishes …

The present study aims to shed light on the origin of abnormal oocytes ovulated by aged
females. In order to reach this goal, cellular and morphological traits of ovulated oocytes …

Purpose Detection of chemical modifications induced by aging-related oxidative damage in
mouse metaphase II (MII) oocytes by Raman microspectroscopy. Methods CD-1 mice at the …

BACKGROUND: The senescence-accelerated mouse (SAM) has been shown to exhibit
ageing-associated mitochondrial dysfunction and oxidative stress, and early decline in …

Reproductive aging is associated with ovulatory defects. Age‐related ovarian fibrosis
partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds …