Screening of fusion partners for high yield expression and purification of bioactive viscotoxins

J Bogomolovas, B Simon, M Sattler, G Stier - Protein expression and …, 2009 - Elsevier
Viscotoxins are small cationic proteins found in European mistletoe Viscum album. They are
highly toxic towards phytopathogenic fungi and cancer cells. Heterologous expression of …

Mistletoe viscotoxins induce membrane permeabilization and spore death in phytopathogenic fungi

AM Giudici, MC Regente, J Villalaín… - Physiologia …, 2004 - Wiley Online Library
Viscotoxins (Vts) are basic peptides expressed in mistletoe leaves, seeds and stems which
have been shown to be cytotoxic to mammalian cells. The aim of this study was to analyse …

Comparative membrane interaction study of viscotoxins A3, A2 and B from mistletoe (Viscum album) and connections with their structures

A Coulon, A Mosbah, A Lopez… - Biochemical …, 2003 - portlandpress.com
Viscotoxins A2 (VA2) and B (VB) are, together with viscotoxin A3 (VA3), among the most
abundant viscotoxin isoforms that occur in mistletoe-derived medicines used in anti-cancer …

Antifungal effects and mechanism of action of viscotoxin A3

M Giudici, J Antonio Poveda, ML Molina… - The FEBS …, 2006 - Wiley Online Library
Viscotoxins are cationic proteins, isolated from different mistletoe species, that belong to the
group of thionins, a group of basic cysteine‐rich peptides of≈ 5 kDa. They have been …

Isolation and characterization of cDNAs encoding viscotoxins of mistletoe (Viscum album)

G Schrader, K Apel - European journal of biochemistry, 1991 - Wiley Online Library
Viscotoxins have been isolated from leaf homogenates of European mistletoe (Viscum
album L.) and purified to apparent homogeneity. Antisera raised against these polypeptides …

High-level expression of a viscotoxin in Arabidopsis thaliana gives enhanced resistance against Plasmodiophora brassicae

S Holtorf, J Ludwig-Müller, K Apel, H Bohlmann - Plant molecular biology, 1998 - Springer
Viscotoxins are a group of toxic thionins found in several mistletoe species. The constitutive
CaMV-Ω promoter was used to drive the expression of the viscotoxin A3 cDNA from Viscum …

[HTML][HTML] Preparation of VT1 and VT2 hybrid toxins from their purified dissociated subunits. Evidence for B subunit modulation of a subunit function

SC Head, MA Karmali, CA Lingwood - Journal of Biological Chemistry, 1991 - Elsevier
Verocytotoxins comprise a family of closely related subunit proteins. Two members of this
group, VT1 and the immunologically distinct VT2, have been found to share similar physical …

[HTML][HTML] Interaction of viscotoxins A3 and B with membrane model systems: implications to their mechanism of action

M Giudici, R Pascual, L de la Canal, K Pfüller… - Biophysical journal, 2003 - cell.com
Viscotoxins are small proteins that are thought to interact with biomembranes, displaying
different toxic activities against a varied number of cell types, being viscotoxin A 3 (VtA 3) the …

Structure of viscotoxin A3: disulfide location from weak SAD data

JÉ Debreczeni, B Girmann, A Zeeck… - … Section D: Biological …, 2003 - journals.iucr.org
The crystal structure of viscotoxin A3 (VT A3) extracted from European mistletoe (Viscum
album L.) has been solved using the anomalous diffraction of the native S atoms measured …

Mistletoe viscotoxins increase natural killer cell‐mediated cytotoxicity

J Tabiasco, F Pont, JJ Fournié… - European Journal of …, 2002 - Wiley Online Library
Mistletoe extracts have immunomodulatory activity. We show that nontoxic concentrations of
Viscum album extracts increase natural killer (NK) cell‐mediated killing of tumor cells but …