Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - ASPET
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
The JAK-STAT pathway: impact on human disease and therapeutic intervention
JJ O'Shea, DM Schwartz, AV Villarino… - Annual review of …, 2015 - annualreviews.org
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
H Yu, H Lee, A Herrmann, R Buettner, R Jove - Nature reviews cancer, 2014 - nature.com
Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential
HT Tzeng, IT Chyuan, JH Lai - Biochemical Pharmacology, 2021 - Elsevier
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is characterized by diverse immune regulatory systems involving cell proliferation …
pathway is characterized by diverse immune regulatory systems involving cell proliferation …
JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance
HE Sabaawy, BM Ryan, H Khiabanian… - …, 2021 - academic.oup.com
Inflammation is at the forefront of carcinogenesis, tumor progression and resistance to
therapy. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) …
therapy. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) …
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
C Xue, Q Yao, X Gu, Q Shi, X Yuan, Q Chu… - Signal transduction and …, 2023 - nature.com
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
is an evolutionarily conserved mechanism of transmembrane signal transduction that …
Targeting JAK/STAT signaling pathway in inflammatory diseases
CJ Malemud, E Pearlman - Current Signal Transduction …, 2009 - ingentaconnect.com
In immune-mediated chronic inflammation the balance between pro-inflammatory and anti-
inflammatory cytokines is skewed so that elevated levels of circulating pro-inflammatory …
inflammatory cytokines is skewed so that elevated levels of circulating pro-inflammatory …
[HTML][HTML] Targeting the JAK/STAT pathway in solid tumors
Z Qureshy, DE Johnson, JR Grandis - Journal of cancer metastasis …, 2020 - ncbi.nlm.nih.gov
Aberrant activation of signal transducer and activator of transcription (STAT) proteins is
associated with the development and progression of solid tumors. However, as transcription …
associated with the development and progression of solid tumors. However, as transcription …