Liquid–liquid phase separation (LLPS) is an important mechanism that helps explain the
membraneless compartmentalization of the nucleus. Because chromatin compaction and …

Liquid-liquid phase separation (LLPS) has been recognized as one of the key cellular
organizing principles and was shown to be responsible for formation of membrane-less …

Nuclear bodies are membraneless condensates that may form via liquid-liquid phase
separation. The viscoelastic chromatin network could impact their stability and may hold the …

Enclosed by two membranes, the nucleus itself is comprised of various membraneless
compartments, including nuclear bodies and chromatin domains. These compartments play …

Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …

Eukaryotic chromatin is highly condensed but dynamically accessible to regulation and
organized into subdomains. We demonstrate that reconstituted chromatin undergoes …

Liquid–liquid phase separation (LLPS) contributes to the spatial and functional segregation
of molecular processes within the cell nucleus. However, the role played by LLPS in …

The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …

In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

Cells organize membrane-less internal compartments through a process called liquid–liquid
phase separation (LLPS) to create chemically distinct compartments, referred to as …