Respiratory depression limits the use of opioid analgesia. Although well described clinically,
the specific mechanisms of opioid action on respiratory control centres in the brain have …

Respiratory depression is the proximal cause of death in opioid overdose, yet the
mechanisms underlying this potentially fatal outcome are not well understood. The goal of …

The ventilatory control system is highly vulnerable to exogenous administered opioid
analgesics. Particularly respiratory depression is a potentially lethal complication that may …

The human body is critically dependent on the ventilatory control system for adequate
uptake of oxygen and removal of carbon dioxide (CO 2). Potent opioid analgesics, through …

Key points The main cause of death from opioid overdose is respiratory depression due to
the activation of µ‐opioid receptors (MORs). We conditionally deleted MORs from neurons in …

Opioids induce respiratory depression via activation of μ-opioid receptors at specific sites in
the central nervous system including the pre-Bötzinger complex, a respiratory rhythm …

Opioid-induced respiratory depression (OIRD), the primary cause of opioid-induced death, is
the neural depression of respiratory drive which, together with a decreased level of …

Opioid-induced respiratory depression (OIRD) causes death following an opioid overdose,
yet the neurobiological mechanisms of this process are not well understood. Here, we show …

Background Opioids are potent painkillers but come with serious adverse effects ranging
from addiction to potentially lethal respiratory depression. A variety of drugs with separate …

Morphine is a drug commonly administered via the epidural or intrathecal route, and is
regarded by many as the 'gold-standard'single-dose neuraxial opioid due to its …