Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay
AM Grabiec, O Korchynskyi, PP Tak… - Annals of the rheumatic …, 2012 - ard.bmj.com
Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in
animal models of arthritis and suppress inflammatory cytokine production in rheumatoid …
animal models of arthritis and suppress inflammatory cytokine production in rheumatoid …
Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes
C Angiolilli, PA Kabala, AM Grabiec… - Annals of the …, 2017 - ard.bmj.com
Objectives Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have
demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid …
demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid …
Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3–selective inhibitor reduces interleukin‐6 production by peripheral …
Objective To characterize the role of histone deacetylase (HDAC) activity in rheumatoid
arthritis (RA) and to evaluate the effects of MI192, a novel HDAC‐3–selective inhibitor …
arthritis (RA) and to evaluate the effects of MI192, a novel HDAC‐3–selective inhibitor …
Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissue
AM Grabiec, S Krausz, W De Jager… - The journal of …, 2010 - journals.aai.org
Macrophages contribute significantly to the pathology of many chronic inflammatory
diseases, including rheumatoid arthritis (RA), asthma, and chronic obstructive pulmonary …
diseases, including rheumatoid arthritis (RA), asthma, and chronic obstructive pulmonary …
Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression
C Angiolilli, AM Grabiec, BS Ferguson… - Annals of the …, 2016 - ard.bmj.com
Objectives Epigenetic modifications play an important role in the regulation of gene
transcription and cellular function. Here, we examined if pro-inflammatory factors present in …
transcription and cellular function. Here, we examined if pro-inflammatory factors present in …
Expression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts
M Horiuchi, A Morinobu, T Chin, Y Sakai… - The Journal of …, 2009 - jrheum.org
Objective. To explore the effects of histone deacetylases (HDAC) on rheumatoid arthritis
synovial fibroblasts (RA-SF). Methods. The expression of mRNA encoding HDAC1 through …
synovial fibroblasts (RA-SF). Methods. The expression of mRNA encoding HDAC1 through …
[HTML][HTML] Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?
AM Grabiec, PP Tak, KA Reedquist - Arthritis research & therapy, 2008 - Springer
Cellular activation, proliferation and survival in chronic inflammatory diseases is regulated
not only by engagement of signal trans-duction pathways that modulate transcription factors …
not only by engagement of signal trans-duction pathways that modulate transcription factors …
[HTML][HTML] Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast …
JH Wang, KS Shih, YW Wu, AW Wang… - Osteoarthritis and …, 2013 - Elsevier
Objective MiR-146a exerts negative control on inflammatory responses by suppressing
cytokine-induced expression of interleukin-1 receptor-associated kinase-1 (IRAK1) and …
cytokine-induced expression of interleukin-1 receptor-associated kinase-1 (IRAK1) and …
[HTML][HTML] Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis
T Kawabata, K Nishida, K Takasugi, H Ogawa… - Arthritis research & …, 2010 - Springer
Introduction The purpose of this study was to investigate the profile of histone deacetylase
(HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of …
(HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of …
[HTML][HTML] Therapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis
JK Park, YJ Jang, BR Oh, J Shin, D Bae, N Ha… - Arthritis research & …, 2020 - Springer
Objectives Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-
arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of …
arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of …
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