The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research

TR Rodrigues Prestes, NP Rocha… - Current drug …, 2017 - ingentaconnect.com
Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …

ACE2, angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis

AC Simões e Silva, KD Silveira… - British journal of …, 2013 - Wiley Online Library
Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …

ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis

ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …

The potential therapeutic use of renin–angiotensin system inhibitors in the treatment of inflammatory diseases

R Ranjbar, M Shafiee, AR Hesari… - Journal of cellular …, 2019 - Wiley Online Library
Inflammation is a normal part of the immune response to injury or infection but its
dysregulation promotes the development of inflammatory diseases, which cause …

ACE2–angiotensin-(1–7)–Mas axis and oxidative stress in cardiovascular disease

LA Rabelo, N Alenina, M Bader - Hypertension Research, 2011 - nature.com
The renin–angiotensin–aldosterone system (RAAS) is a pivotal regulator of physiological
homeostasis and diseases of the cardiovascular system. Recently, new factors have been …

Role of renin-angiotensin system components in atherosclerosis: focus on Ang-II, ACE2, and Ang-1–7

GM Silva, MS França-Falcão, NTM Calzerra… - Frontiers in …, 2020 - frontiersin.org
Atherosclerosis is the leading cause of vascular disease worldwide and contributes
significantly to deaths from cardiovascular complications. There is a remarkably close …

[HTML][HTML] Angiotensin-(1-7) attenuates angiotensin II-induced ICAM-1, VCAM-1, and MCP-1 expression via the MAS receptor through suppression of P38 and NF-κB …

B Liang, X Wang, N Zhang, H Yang, R Bai… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Atherosclerosis is a chronic inflammatory disease. Intracellular adhesion
molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte …

The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor axis as a key player in alveolar bone remodeling

CM Queiroz-Junior, ACPM Santos, I Galvão, GR Souto… - Bone, 2019 - Elsevier
The renin-angiotensin system (RAS), aside its classical hormonal properties, has been
implicated in the pathogenesis of inflammatory disorders. The angiotensin converting …

Anti-inflammatory effects of the activation of the angiotensin-(1–7) receptor, MAS, in experimental models of arthritis

KD da Silveira, FM Coelho, AT Vieira… - The Journal of …, 2010 - journals.aai.org
Activation of the renin-angiotensin (Ang) system induces inflammation via interaction
between Ang II and type 1 receptor on leukocytes. The relevance of the new arm of the renin …

Renin-angiotensin system and inflammation update

E Cantero-Navarro, B Fernandez-Fernandez… - Molecular and cellular …, 2021 - Elsevier
The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. However, it has long become …