Modulating interactions between ligand-coated nanoparticles and phase-separated lipid bilayers by varying the ligand density and the surface charge

X Chen, DP Tieleman, Q Liang - Nanoscale, 2018 - pubs.rsc.org
The interactions between nanoparticles and lipid bilayers are critical in applications of
nanoparticles in nanomedicine, cell imaging, toxicology, and elsewhere. Here, we …

Curvature-driven adsorption of cationic nanoparticles to phase boundaries in multicomponent lipid bilayers

JK Sheavly, JA Pedersen, RC Van Lehn - Nanoscale, 2019 - pubs.rsc.org
Understanding the interactions between surface-functionalized gold nanoparticles (NPs)
and lipid bilayers is necessary to guide the design of NPs for biomedical applications …

Penetration of lipid bilayers by nanoparticles with environmentally-responsive surfaces: simulations and theory

RC Van Lehn, A Alexander-Katz - Soft Matter, 2011 - pubs.rsc.org
Understanding the interactions between nanoparticles (NPs) and lipid bilayers is critical for
the design of drug delivery carriers, biosensors, and biocompatible materials. In particular, it …

The aggregation of striped nanoparticles in mixed phospholipid bilayers

SY Noh, A Nash, R Notman - Nanoscale, 2020 - pubs.rsc.org
The unique and adjustable properties of nanoparticles present enormous opportunities for
their use as targeted drug delivery vectors. For example, nanoparticles functionalized with …

Lipophilicity of cationic ligands promotes irreversible adsorption of nanoparticles to lipid bilayers

CA Lochbaum, AK Chew, X Zhang, V Rotello… - ACS …, 2021 - ACS Publications
A mechanistic understanding of the influence of the surface properties of engineered
nanomaterials on their interactions with cells is essential for designing materials for …

Self-assembly of anionic, ligand-coated nanoparticles in lipid membranes

P Angelikopoulos, L Sarkisov, Z Cournia, P Gkeka - Nanoscale, 2017 - pubs.rsc.org
Ligand-functionalized nanoparticles (NPs) are a promising platform for imaging and drug
delivery applications. A number of recent molecular simulation and theoretical studies …

[HTML][HTML] Membrane partitioning of anionic, ligand-coated nanoparticles is accompanied by ligand snorkeling, local disordering, and cholesterol depletion

P Gkeka, P Angelikopoulos, L Sarkisov… - PLoS computational …, 2014 - journals.plos.org
Intracellular uptake of nanoparticles (NPs) may induce phase transitions, restructuring,
stretching, or even complete disruption of the cell membrane. Therefore, NP cytotoxicity …

Ligand Lipophilicity Determines Molecular Mechanisms of Nanoparticle Adsorption to Lipid Bilayers

CA Huang-Zhu, JK Sheavly, AK Chew, SJ Patel… - ACS …, 2024 - ACS Publications
The interactions of ligand-functionalized nanoparticles with the cell membrane affect cellular
uptake, cytotoxicity, and related behaviors, but relating these interactions to ligand …

Nanoparticles self-assembly within lipid bilayers

H Chan, P Král - Acs Omega, 2018 - ACS Publications
Coarse-grained molecular dynamics simulations are used to model the self-assembly of
small hydrophobic nanoparticles (NPs) within the interior of lipid bilayers. The simulation …

Membrane-specific binding of 4 nm lipid nanoparticles mediated by an entropy-driven interaction mechanism

L Ou, H Chen, B Yuan, K Yang - ACS nano, 2022 - ACS Publications
Lipid nanoparticles (LNPs) are a leading biomimetic drug delivery platform due to their
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …