Modulating interactions between ligand-coated nanoparticles and phase-separated lipid bilayers by varying the ligand density and the surface charge
X Chen, DP Tieleman, Q Liang - Nanoscale, 2018 - pubs.rsc.org
The interactions between nanoparticles and lipid bilayers are critical in applications of
nanoparticles in nanomedicine, cell imaging, toxicology, and elsewhere. Here, we …
nanoparticles in nanomedicine, cell imaging, toxicology, and elsewhere. Here, we …
Curvature-driven adsorption of cationic nanoparticles to phase boundaries in multicomponent lipid bilayers
JK Sheavly, JA Pedersen, RC Van Lehn - Nanoscale, 2019 - pubs.rsc.org
Understanding the interactions between surface-functionalized gold nanoparticles (NPs)
and lipid bilayers is necessary to guide the design of NPs for biomedical applications …
and lipid bilayers is necessary to guide the design of NPs for biomedical applications …
Penetration of lipid bilayers by nanoparticles with environmentally-responsive surfaces: simulations and theory
RC Van Lehn, A Alexander-Katz - Soft Matter, 2011 - pubs.rsc.org
Understanding the interactions between nanoparticles (NPs) and lipid bilayers is critical for
the design of drug delivery carriers, biosensors, and biocompatible materials. In particular, it …
the design of drug delivery carriers, biosensors, and biocompatible materials. In particular, it …
The aggregation of striped nanoparticles in mixed phospholipid bilayers
The unique and adjustable properties of nanoparticles present enormous opportunities for
their use as targeted drug delivery vectors. For example, nanoparticles functionalized with …
their use as targeted drug delivery vectors. For example, nanoparticles functionalized with …
Lipophilicity of cationic ligands promotes irreversible adsorption of nanoparticles to lipid bilayers
A mechanistic understanding of the influence of the surface properties of engineered
nanomaterials on their interactions with cells is essential for designing materials for …
nanomaterials on their interactions with cells is essential for designing materials for …
Self-assembly of anionic, ligand-coated nanoparticles in lipid membranes
Ligand-functionalized nanoparticles (NPs) are a promising platform for imaging and drug
delivery applications. A number of recent molecular simulation and theoretical studies …
delivery applications. A number of recent molecular simulation and theoretical studies …
[HTML][HTML] Membrane partitioning of anionic, ligand-coated nanoparticles is accompanied by ligand snorkeling, local disordering, and cholesterol depletion
Intracellular uptake of nanoparticles (NPs) may induce phase transitions, restructuring,
stretching, or even complete disruption of the cell membrane. Therefore, NP cytotoxicity …
stretching, or even complete disruption of the cell membrane. Therefore, NP cytotoxicity …
Ligand Lipophilicity Determines Molecular Mechanisms of Nanoparticle Adsorption to Lipid Bilayers
The interactions of ligand-functionalized nanoparticles with the cell membrane affect cellular
uptake, cytotoxicity, and related behaviors, but relating these interactions to ligand …
uptake, cytotoxicity, and related behaviors, but relating these interactions to ligand …
Nanoparticles self-assembly within lipid bilayers
Coarse-grained molecular dynamics simulations are used to model the self-assembly of
small hydrophobic nanoparticles (NPs) within the interior of lipid bilayers. The simulation …
small hydrophobic nanoparticles (NPs) within the interior of lipid bilayers. The simulation …
Membrane-specific binding of 4 nm lipid nanoparticles mediated by an entropy-driven interaction mechanism
L Ou, H Chen, B Yuan, K Yang - ACS nano, 2022 - ACS Publications
Lipid nanoparticles (LNPs) are a leading biomimetic drug delivery platform due to their
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …
distinctive advantages and highly tunable formulations. A mechanistic understanding of the …
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