New β-carboline derivatives as potential α-glucosidase inhibitor: Synthesis and biological activity evaluation
J Lin, D Xiao, L Lu, B Liang, Z Xiong, X Xu - Journal of Molecular Structure, 2023 - Elsevier
Abstract α-Glucosidase is an important therapeutic target of diabetes mellitus. To find potent
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …
Identification of 1, 3, 4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity
D Xiao, L Lu, B Liang, Z Xiong, X Xu… - European Journal of …, 2023 - Elsevier
In this study, we designed and synthesized a novel class of 1, 3, 4-oxadiazolyl-containing β-
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
Synthesis and biological evaluation of novel 1, 2, 4-triazine derivatives bearing carbazole moiety as potent α-glucosidase inhibitors
G Wang, J Wang, D He, X Li, J Li, Z Peng - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract A new series of 1, 2, 4-triazine derivatives bearing carbazole moiety 7a–7p were
designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. The majority …
designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. The majority …
Anti-α-glucosidase, SAR analysis, and mechanism investigation of indolo [1, 2-b] isoquinoline derivatives
M Li, L Li, L Lu, X Xu, J Hu, JB Peng - Molecules, 2023 - mdpi.com
To find potential α-glucosidase inhibitors, indolo [1, 2-b] isoquinoline derivatives (1–20)
were screened for their α-glucosidase inhibitory effects. All derivatives presented potential α …
were screened for their α-glucosidase inhibitory effects. All derivatives presented potential α …
Design and synthesis of novel pyrazole-phenyl semicarbazone derivatives as potential α-glucosidase inhibitor: Kinetics and molecular dynamics simulation study
A series of novel pyrazole-phenyl semicarbazone derivatives were designed, synthesized,
and screened for in vitro α-glucosidase inhibitory activity. Given the importance of hydrogen …
and screened for in vitro α-glucosidase inhibitory activity. Given the importance of hydrogen …
Chromone-based benzohydrazide derivatives as potential α-glucosidase inhibitor: Synthesis, biological evaluation and molecular docking study
M Fan, W Yang, Z Peng, Y He, G Wang - Bioorganic Chemistry, 2023 - Elsevier
In order to find new α-glucosidase inhibitors with high efficiency and low toxicity, novel
chromone-based benzohydrazide derivatives 6a-6s were synthesized and characterized …
chromone-based benzohydrazide derivatives 6a-6s were synthesized and characterized …
Synthesis, biological evaluation and molecular docking studies of chromone derivatives as potential α-glucosidase inhibitors
M Fan, X Zhong, Y Huang, Z Peng, G Wang - Journal of Molecular Structure, 2023 - Elsevier
A series of chromone derivatives were designed, synthesized, and evaluated for their α-
glucosidase inhibitory activity by using in vitro methods and molecular docking studies …
glucosidase inhibitory activity by using in vitro methods and molecular docking studies …
Novel cinnamic acid magnolol derivatives as potent α-glucosidase and α-amylase inhibitors: Synthesis, in vitro and in silico studies
CM Hu, WJ Wang, YN Ye, Y Kang, J Lin, PP Wu… - Bioorganic …, 2021 - Elsevier
In this study, twenty novel cinnamic acid magnolol derivatives were synthesized, and
screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good …
screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good …
Design, synthesis, biological evaluation, and docking study of new triazole-phenylacetamide derivatives as α-glucosidase inhibitors
S Luo, W Yang, Y Huang, Z Peng, G Wang - Bioorganic Chemistry, 2023 - Elsevier
To discover potent α-glucosidase inhibitors, a class of novel triazole-phenylacetamide
derivatives (5a-5p) were designed, prepared, and tested for their α-glucosidase inhibitory …
derivatives (5a-5p) were designed, prepared, and tested for their α-glucosidase inhibitory …
Design, synthesis, biological evaluation, and docking study of chromone-based phenylhydrazone and benzoylhydrazone derivatives as antidiabetic agents targeting α …
M Fan, W Yang, L Liu, Z Peng, Y He, G Wang - Bioorganic Chemistry, 2023 - Elsevier
To develop novel α-glucosidase inhibitors, a series of chromone-based phenylhydrazone
and benzoylhydrazone derivatives were designed, synthesized, and evaluated their …
and benzoylhydrazone derivatives were designed, synthesized, and evaluated their …
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