Chemical modifications to mRNA nucleobases impact translation elongation and termination
MK Franco, KS Koutmou - Biophysical chemistry, 2022 - Elsevier
Messenger RNAs (mRNAs) serve as blueprints for protein synthesis by the molecular
machine the ribosome. The ribosome relies on hydrogen bonding interactions between …
machine the ribosome. The ribosome relies on hydrogen bonding interactions between …
How 2'-O-Methylation in mRNA Disrupts tRNA Decoding during Translation Elongation
Chemical modifications of messenger RNA (mRNA) may regulate many aspects of mRNA
processing and protein synthesis. Recently, 2'-O-methylation (Nm) of nucleotides was …
processing and protein synthesis. Recently, 2'-O-methylation (Nm) of nucleotides was …
Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation
JD Jones, MK Franco, TJ Smith, LR Snyder… - RSC Chemical …, 2023 - pubs.rsc.org
Chemical modifications to protein encoding messenger RNAs (mRNAs) influence their
localization, translation, and stability within cells. Over 15 different types of mRNA …
localization, translation, and stability within cells. Over 15 different types of mRNA …
Eukaryotic translation elongation is modulated by single natural nucleotide derivatives in the coding sequences of mRNAs
TP Hoernes, D Heimdörfer, D Köstner, K Faserl… - Genes, 2019 - mdpi.com
RNA modifications are crucial factors for efficient protein synthesis. All classes of RNAs that
are involved in translation are modified to different extents. Recently, mRNA modifications …
are involved in translation are modified to different extents. Recently, mRNA modifications …
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
N 6-methylation of adenosine (forming m6A) is the most abundant post-transcriptional
modification within the coding region of mRNA, but its role during translation remains …
modification within the coding region of mRNA, but its role during translation remains …
Messenger RNA structure regulates translation initiation: a mechanism exploited from bacteria to humans
RNAs (mRNAs) play a central role in directing this regulation. Through instructions that
remain largely cryptic, mRNA transcripts modulate the initiation process to achieve a specific …
remain largely cryptic, mRNA transcripts modulate the initiation process to achieve a specific …
Translation rate is controlled by coupled trade-offs between site accessibility, selective RNA unfolding and sliding at upstream standby sites
A Espah Borujeni, AS Channarasappa… - Nucleic acids …, 2014 - academic.oup.com
The ribosome's interactions with mRNA govern its translation rate and the effects of post-
transcriptional regulation. Long, structured 5′ untranslated regions (5′ UTRs) are …
transcriptional regulation. Long, structured 5′ untranslated regions (5′ UTRs) are …
The ribosome in action: Tuning of translational efficiency and protein folding
MV Rodnina - Protein Science, 2016 - Wiley Online Library
Marina V. Rodnina is the winner of the 2015 Hans Neurath Award. Abstract The cellular
proteome is shaped by the combined activities of the gene expression and quality control …
proteome is shaped by the combined activities of the gene expression and quality control …
Modulation of translational decoding by m6A modification of mRNA
Abstract N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that
regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding regions inhibits …
regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding regions inhibits …
Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation
Reversible methylation of the N 6 or N 1 position of adenine in RNA has recently been
shown to play significant roles in regulating the functions of RNA. RNA can also be alkylated …
shown to play significant roles in regulating the functions of RNA. RNA can also be alkylated …