Aminopyrimidines as Syk inhibitors
MD Altman, KL Arrington, J Burch, B Cote… - US Patent …, 2014 - Google Patents
Spleen Tyrosine Kinase (Syk) is a protein tyrosine kinase which has been described as a
key mediator of immunorecep tor signalling in a host of inflammatory cells including mast …
key mediator of immunorecep tor signalling in a host of inflammatory cells including mast …
Prodrug bipyridylaminopyridines as syk inhibitors
AM Haidle, B Cash, JP Jewell, K Spencer… - US Patent App. 14 …, 2015 - Google Patents
0001 Spleen Tyrosine Kinase (Syk) is a protein tyrosine kinase which has been described
as a key mediator of immu noreceptor signalling in a host of inflammatory cells includ ing …
as a key mediator of immu noreceptor signalling in a host of inflammatory cells includ ing …
Syk inhibitors as treatment for allergic rhinitis
ES Masuda, J Schmitz - Pulmonary pharmacology & therapeutics, 2008 - Elsevier
Allergic rhinitis is characterized by a hypersensitive immune response in the upper airways
to seasonal or perennial allergens leading to episodes of sneezing, itching, runny nose and …
to seasonal or perennial allergens leading to episodes of sneezing, itching, runny nose and …
1, 6 naphthyridines useful as inhibitors of SYK kinase
CL Cywin, SE Jakes, J Heider, MA Bobko… - US Patent …, 2010 - Google Patents
R8 wherein RRR, and Rs are defined herein, which are useful as inhibitors SYK kinase and
are thus useful for treating diseases resulting from inappropriate mast cell activation, which …
are thus useful for treating diseases resulting from inappropriate mast cell activation, which …
Pyrimidinecarboxamide derivatives as inhibitors of SYK kinase
FL Atkinson, VK Patel - US Patent 8,470,835, 2013 - Google Patents
This application is filed pursuant to 35 USC S371 as a United States National Phase
Application of International Patent Application No. PCT/EP2010/050228 filed Jan. 11, 2010 …
Application of International Patent Application No. PCT/EP2010/050228 filed Jan. 11, 2010 …
Syk kinase inhibitors in allergic diseases.
J Denyer, V Patel - Drug news & perspectives, 2009 - europepmc.org
Recent advances in the understanding of allergic mechanisms have highlighted the role of
immunoglobulin E (IgE) signaling in the mast cell. One of the most important kinases in the …
immunoglobulin E (IgE) signaling in the mast cell. One of the most important kinases in the …
Spleen tyrosine kinase (SYK) biology, inhibitors and therapeutic applications
R Singh, ES Masuda - Annual Reports in Medicinal Chemistry, 2007 - Elsevier
Publisher Summary This chapter discusses the biology of spleen tyrosine kinase (Syk), its
inhibitors and therapeutic applications. The most understood function of Syk kinase activity …
inhibitors and therapeutic applications. The most understood function of Syk kinase activity …
Syk inhibitors.
K Chihara, Y Kimura, C Honjo, K Takeuchi… - Nihon Rinsho Men'eki …, 2013 - europepmc.org
Non-receptor type of protein-tyrosine kinase Syk (spleen tyrosine kinase) was isolated in
University of Fukui in 1991. Syk is most highly expressed by haemopoietic cells and known …
University of Fukui in 1991. Syk is most highly expressed by haemopoietic cells and known …
Syk inhibitors
PA Blomgren, A Clarke, KS Currie, J Di Paolo… - US Patent …, 2016 - Google Patents
BACKGROUND Protein kinases, the largest family of human enzymes, encompass well over
500 proteins. Spleen Tyrosine Kinase (Syk) is a member of the Syk family of tyrosine …
500 proteins. Spleen Tyrosine Kinase (Syk) is a member of the Syk family of tyrosine …
Syk inhibitors
PA Blomgren, A Clarke, KS Currie, JA Di Paolo… - US Patent …, 2018 - Google Patents
BACKGROUND Protein kinases, the largest family of human enzymes, 20 encompass well
over 500 proteins. Spleen Tyrosine Kinase (Syk) is a member of the Syk family of tyrosine …
over 500 proteins. Spleen Tyrosine Kinase (Syk) is a member of the Syk family of tyrosine …